Molecular genetics in neurobiology has developed rapidly with the introduction of the new and productive methodologies of genetic engineering and cell manipulation. Particularly in the field of developmental neurobiology, molecular genetics has had impact in research on the molecular mechanism of development and differentiation in the nervous system. This volume comprises 20 articles grouped into the following areas: cell recognition, embryo and gene manipulation, gene analysis and manipulation, and neural recognition. The authors have reviewed and interpreted their most recent results reflecting new concepts and ideas in the molecular approach to neurobiology.
Preface CELL RECOGNITION Structure and molecular biology of cell adhesion molecules J.J. Hamperly, G.C. Owens and B.A. Cunningham Morphogenetic roles of calcium-dependent cell--cell adhesion molecules M. Takeichi, Y. Shirayoshi, K. Hatta and A. Nose Biochemical characterization of the adrenergic receptors: Regulation of responsiveness by phosphorylation of the receptors M.G. Caron, J.L. Benovic, L.M.F. Leeb-Lundberg, R.A. Cerione, J.W. Regan, J.W. Lomasney, S. Cotecchia, H. Nakata, D.R. Sibley, R.H. Strasser and R.J. Lefkowitz EMBRYO MANIPULATION A genetic approach to development of the mammalian CNS: Studies of cell lineage and cell:cell interaction in the regulation of cell number K. Herrup Production of chimeras using newly established teratocarcinoma lines H. Hanaoka, M. Hayasaka, S. Kondo, T. Noguchi and Y. Kato Transgenic mice carrying human -globin genes H. Tojo, K. Momoi, Y. Fukumaki and Z. Ogita EMBRYO AND GENE MANIPULATION Genetic manipulations in mammalian development D. Solter Transgenic mice transferred with the cloned gene expressed in B lymphocytes K. Yamamura, T. Ebihara, K. Kamino and Y. Kumahara Normal and mutant genes for the mouse myelin basic proteins A. Roach, N. Takahashi, S.B. Prusiner and L.E. Hood Structure and expression of the myelin basic protein gene in mouse M. Kimura, M. Katsuki, H. Inoko, S. Ando, T. Sato, T. Hirose, S. Inayama, H. Takashima, K. Takamatsu, K. Mikoshiba, Y. Tsukada, M. Yokoyama and I. Watanabe GENE ANALYSIS AND MANIPULATION Alternative RNA processing events in calcitonin/CGRP gene expression: A strategy for developmental regulation of neuroendocrine gene expression S.E. Leff, A.F. Russo, R.M. Evans and M.G. Rosenfeld Substance P precursor and kininogen: Their structures, gene organizations, and expressions S. Nakanishi, N. Kitamura, H. Ohkubo, H. Nawa, Y. Takagaki, S. Furuto-Kato and R. Kageyama Cloning and characterization of retina-specific cDNAs N. Miki, C.-H. Kuo, Y. Nakagawa, M.W. Bitensky, K. Ishii, S. Shiosaka and M. Tohyama Expression of the vasopressin presursor gene in normal and diabetes insipidus rats H. Schmale, R. Ivell, G. Higgins and D. Richter Inefficient transcription of the myelin basic protein (MBP) gene is a possible cause of hypomyelination in myelin deficient (mld) mutant mice H. Okano, M. Miura, K. Mikoshiba, Y. Inoue, M. Fujishiro and Y. Tsukada Molecular biology of phenylalanine hydroxylase and phenylketonuria F.D. Ledley, A.G. DiLella and S.L.C. Woo Molecular pathogenesis of familial amyloidotic polyneuropathy S. Maeda, S. Mita, S. Wakasugi, T. Tsuzuki, M. Ide, S. Araki and K. Shimada Gene expression in the mammalian brain S. Forss-Petter, R.D. McKinnon, A.-P. Tsou, G. Travis, M.A. Brow, M. Kiel, P. Danielson and J.G. Sutcliffe Molecular cloning and nucleotide sequences of cDNA and genomic DNA for and subunits of S100 protein R. Kuwano, H. Usui, T. Maeda, K. Araki, T. Kurihara, T. Yamakuni, E. Ohtsuka, M. Ikehara and Y. Takahashi NEURAL REGENERATION Axonal regeneration in the adult mammalian central nervous system: Anatomical and functional studies A.J. Aguayo Subject index Author index