Protein Folding and Metal Ions: Mechanisms, Biology and Disease, 1st Edition (e-Book) book cover

Protein Folding and Metal Ions

Mechanisms, Biology and Disease, 1st Edition

Edited by Claudio M. Gomes, Pernilla Wittung-Stafshede

CRC Press

308 pages

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pub: 2010-10-05
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Description

The role of metal ions in protein folding and structure is a critical topic to a range of scientists in numerous fields, particularly those working in structural biology and bioinorganic chemistry, those studying protein folding and disease, and those involved in the molecular and cellular aspects of metals in biological systems. Protein Folding an

Table of Contents

FOLDING AND STABILITY OF METALLOPROTEINS : Metal Ions, Protein Folding, and Conformational States: An Introduction. The Folding Mechanism of c-Type Cytochromes. The Mechanism of Cytochrome c Folding: Early Events and Kinetic Intermediates. Stability and Folding of Copper-Binding Proteins. Iron-Sulfur Clusters, Protein Folds, and Ferredoxin Stability. Folding and Stability of Myoglobins and Hemoglobins. MECHANISMS OF METAL TRANSPORTERS, AND ASSEMBLY: Frataxin: An Unusual Metal-Binding Protein in Search of a Function. Mechanism of Human Copper Transporter Wilson's Disease Protein. METAL IONS, PROTEIN CONFORMATION, AND DISEASE: a-Synuclein and Metals.Zinc and Misfolding. The Octarepeat Domain of the Prion Protein and Its Role in Metal Ion Coordination and Disease. METALLOPROTEIN DESIGN, SIMULATION, AND MODELS: Metallopeptides as Tools to Understand Metalloprotein Folding and Stability. The Folding Landscapes of Metalloproteins.

About the Editors

Claudio M. Gomes is group leader at the Instituto Tecnologia Quimica e Biologica, a research institute affiliated with the Universidade Nova de Lisboa, Oeiras, Portugal. Born in 1970, Claudio earned his PhD from the Instituto Tecnologia Quimica e Biologica in 1999, as a Gulbenkian PhD program in biology and medicine graduate. From 2000 onward, he gradually switched his research interests from bioenergetics and metalloprotein structure-function toward protein folding and structural biophysics of misfolding diseases. Until setting up his independent laboratory in 2003, he was assistant professor at the Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, where he started teaching in 2000. Claudio has published more than 70 peer-reviewed papers.

Pernilla Wittung-Stafshede has been a professor in biological chemistry in the Chemistry Department at Ume?niversity, Ume?Sweden since 2008. Born in 1968, she earned a PhD in physical chemistry from Chalmers University, Gothenburg, Sweden, in 1996. During 1997-1998, she did a postdoctoral period at Caltech, Pasadena, California. In 1999 she began her independent research career, with a focus on the role of metals in protein folding, as a chemistry professor at Tulane University, New Orleans, Louisiana. After 5 years at Tulane, she moved to Rice University, Houston, Texas in 2004 and became a professor in biochemistry. Pernilla has graduated 10 PhD students to date, has obtained several awards, and has published over 150 peer-reviewed papers.

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
SCI013030
SCIENCE / Chemistry / Inorganic
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology
SCI055000
SCIENCE / Physics