Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies, 1st Edition (Hardback) book cover

Protein Misfolding in Neurodegenerative Diseases

Mechanisms and Therapeutic Strategies, 1st Edition

Edited by Robert D. E. Sewell

CRC Press

592 pages | 80 B/W Illus.

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Hardback: 9780849373107
pub: 2007-12-03
eBook (VitalSource) : 9780429126796
pub: 2007-12-03
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Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact.

Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS.

A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding

Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.


"…This book will be useful for researchers in protein chemistry and biochemistry, molecular biologists and physicians, and teachers and students of medical schools and universities specialized in proteomics."

—G. Ya. Wiederschain, Doctor of Biological Sciences, in Biochemistry, 2008, Vol. 73, No. 12

Table of Contents

Protein Folding and Misfolding, Relevance to Disease and Function Massimi Stefani

Alzheimer’s Disease Charlotte E. Teunissen and Tischa M. van der Cammen

Improving Cholinergic Transmission

Cholinergic Transmission and Acetylcholine release Enhancers Pierre Francotte, Pascal de Tullio and Bernard Pirotte

AChE and its Inhibition Jure Stojan

AChE Inhibitors and their Clinical Assessment Pierre Francotte, Pascal de Tullio and Bernard Pirotte

Reduction in Plaque Formation Christian Czech, Helmut Jacobsen and Celine Adessi

Non-Steroidal Anti-inflammatory Drugs (NSAIDs) Bruno P. Imbimbo and Francesca Speroni

Hydroxy-3-Methyl-Glutaryl-Coenzyme Reductase Inhibitors Dario Cattaneo

Aβ Polymerization Reduction Harry LeVine III and Corrine E. Augelli-Szafran

Carbonic Anhydrase Activators as Potential Anti-Alzheimer’s Disease Agents

Claudiu T. Supuran and Andrea Scozzafava

Detection and Reduction of Neurofibrillary Lesions Jeff Kuret

Protein Misfolding in Alzheimer Disease: Pathogenic or Protective? Rudy J. Castellani, Hyoung-Gon Lee, Akihiko Nunomura, Xiongwei Zhu, Gorge Perry, and Mark A. Smith

Enhancement of Brain Retinoic Acid Levels Ann B. Goodman, Peter McCaffery, Joana A. Palha, Claire Simons and Arthur B. Pardee

Parkinson’s Disease: What is it? What Causes it? And How Can it be Cured? Tom Foltynie, Andrew W. Michell and Roger A. Barker

Restoring Dopamine Levels Nuno Palma, Maria João Bonifácio, Luís Almeida and Patrício Soares-da-Silva

Huntington’s Disease Claire-Anne Gutekunst and Fran Norflus

Amyotrophic Lateral Sclerosis (Motor neuron Disease) Teresa Sanelli, Janice Robertson, Avi Chakabartty and Michael J Strong

Transmissible Spongiform Encephalopathies (TSEs) Michael D. Geschwind and Giuseppe Legname

Overview H. John Smith, Claire Simons and Robert D.E. Sewell

About the Series

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biochemistry
SCIENCE / Chemistry / General
SCIENCE / Life Sciences / Neuroscience