592 pages | 80 B/W Illus.
Research focused on protein folding, misfolding, and aggregation is leading to major advances across biochemistry and medicine. The elucidation of a folding code is proving to be of extreme importance in the postgenomic era, where a number of orphan genes have been identified for which no clear function has yet been established. This research is starting to shed light on the molecular and biochemical basis of a number of neurodegenerative diseases of dramatic impact.
Protein Misfolding in Neurodegenerative Diseases: Mechanisms and Therapeutic Strategies addresses key issues concerning protein misfolding and aggregation in neurodegenerative diseases. Building on recent developments, including the recognition of protein misfolding as both a marker and a causal agent, the text presents the work of those who are actively pursuing more effective treatments, as well as preventative measures, and a possible cure. These include the use of molecular chaperones to control misfolding and novel pharmaceuticals, as well as the potential role of various inhibitors and NSAIDS.
A Comprehensive Multifaceted Examination of the Complex Causal Agents Implicated in Protein Misfolding
Divided into five sections, this groundbreaking text provides up-to-date accounts for Alzheimer’s, Parkinson’s, Huntington’s, Amyotrophic Lateral Sclerosis and Transmissible Spongiform Encephalitis. It also explores the highly likelihood that multiple factors, including oxidative stress, play a role in these complex diseases.
"…This book will be useful for researchers in protein chemistry and biochemistry, molecular biologists and physicians, and teachers and students of medical schools and universities specialized in proteomics."
—G. Ya. Wiederschain, Doctor of Biological Sciences, in Biochemistry, 2008, Vol. 73, No. 12
Protein Folding and Misfolding, Relevance to Disease and Function Massimi Stefani
Alzheimer’s Disease Charlotte E. Teunissen and Tischa M. van der Cammen
Improving Cholinergic Transmission
Cholinergic Transmission and Acetylcholine release Enhancers Pierre Francotte, Pascal de Tullio and Bernard Pirotte
AChE and its Inhibition Jure Stojan
AChE Inhibitors and their Clinical Assessment Pierre Francotte, Pascal de Tullio and Bernard Pirotte
Reduction in Plaque Formation Christian Czech, Helmut Jacobsen and Celine Adessi
Non-Steroidal Anti-inflammatory Drugs (NSAIDs) Bruno P. Imbimbo and Francesca Speroni
Hydroxy-3-Methyl-Glutaryl-Coenzyme Reductase Inhibitors Dario Cattaneo
Aβ Polymerization Reduction Harry LeVine III and Corrine E. Augelli-Szafran
Carbonic Anhydrase Activators as Potential Anti-Alzheimer’s Disease Agents
Claudiu T. Supuran and Andrea Scozzafava
Detection and Reduction of Neurofibrillary Lesions Jeff Kuret
Protein Misfolding in Alzheimer Disease: Pathogenic or Protective? Rudy J. Castellani, Hyoung-Gon Lee, Akihiko Nunomura, Xiongwei Zhu, Gorge Perry, and Mark A. Smith
Enhancement of Brain Retinoic Acid Levels Ann B. Goodman, Peter McCaffery, Joana A. Palha, Claire Simons and Arthur B. Pardee
Parkinson’s Disease: What is it? What Causes it? And How Can it be Cured? Tom Foltynie, Andrew W. Michell and Roger A. Barker
Restoring Dopamine Levels Nuno Palma, Maria João Bonifácio, Luís Almeida and Patrício Soares-da-Silva
Huntington’s Disease Claire-Anne Gutekunst and Fran Norflus
Amyotrophic Lateral Sclerosis (Motor neuron Disease) Teresa Sanelli, Janice Robertson, Avi Chakabartty and Michael J Strong
Transmissible Spongiform Encephalopathies (TSEs) Michael D. Geschwind and Giuseppe Legname
Overview H. John Smith, Claire Simons and Robert D.E. Sewell