Proteins of Iron Metabolism: 1st Edition (Hardback) book cover

Proteins of Iron Metabolism

1st Edition

By Ugo Testa

CRC Press

608 pages | 60 B/W Illus.

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pub: 2001-09-25
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Description

Proteins of Iron Metabolism presents a clear picture of the structure and function of the main proteins involved in iron metabolism. The book gives you a detailed description of the structure and function of each protein, and discusses the structure and regulation of the corresponding genes in parallel. It supplies an analysis of the differential expression and regulation of these proteins.

Numerous figures offer an integrated view of iron metabolism at the level of various tissues. The book delineates the mechanisms controlling cellular iron metabolism and shows how these mechanisms adapt to the differential and peculiar iron need of different cell types. Each chapter contains extensive bibliographical information providing a wide reference to the literature.

The comprehensive coverage of the advances in understanding the mechanisms controlling cellular iron metabolism, especially at the molecular level, found in this book will give you insight into the regulation of iron metabolism. Proteins of Iron Metabolism fills the need for a clearly written, comprehensive review of the latest research, putting every thing you need in one easy-to-use resource.

Reviews

"This very comprehensive and well-integrated book, written by a single author, explores all of these issues with authority and in great depth. …The references are extensive and the index is good. …a valuable reference on a topic of major importance."

- Food and Nutrition Bulletin, 2002, The United Nations

Table of Contents

IRON ABSORPTION

Introduction

Iron Requirements

Iron Digestion

Iron Absorption

Physiologic Regulation of Iron Absorption

Iron Bioavailability

Absorption of Heme Iron

References

IRON AND CELL PROLIFERATION: MECHANISMS AND APPLICATIONS IN CANCER THERAPY

Introduction

Ribonucleotide Reductase: A Key Enzyme in the Control of DNA Synthesis

Iron and Cell Cycle Control

Inhibition of Cell Proliferation by Agents that Reduce Cellular Iron Incorporation

Iron and Cancer

References

LACTOFERRIN

Introduction

Biochemistry and Molecular Biology of Lactoferrin

Lactoferrin Receptors

Functions of Lactoferrin

Lactoferrin Expression in Neutrophils and Mammary Glands

Lactoferrin Expression during Development

References

TRANSFERRIN

Introduction

Comparative Analysis of the Structures of Transferrin Family Proteins

Transferrin Genetic Variants

Biochemical Properties of Serum Transferrin

Transferrin Gene Expression

Transferrin and Microbiology

Transferrin as a Growth Factor

Congenital Atransferrinemia

Transferrin as a Transporter of Drugs

References

TRANSFERRIN RECEPTOR

Introduction

General Features

Molecular Biology

Transferrin Receptor Glycosylation

Trandferrin Receptor Endocytosis

Transferrin Receptor Phosphorylation

Intracellular Pools of Transferrin Receptors

Effect of Ca2+ and Oxidation on Transferrin Receptor Internalization

Tissue Distribution and Expression on Selected Cell Types

Regulation of Transferrin Receptors

Expression and Regulation in Different Cell Types

Interaction between Transferrin Receptors and HFE: The Class I MHC-Related Protein Mutated in Hereditary Hemochromatosis

A General Overview of Iron Uptake Mechanisms in Various Cell Types

References

SOLUBLE TRANSFERRIN RECEPTOR

Introduction

Generation of Soluble Transferrin Receptor

Circulation in Human Serum

Clinical Relevance

References

ALTERNATIVE IRON UPTAKE SYSTEMS

Transferrin-Idependent Iron Uptake

Proton-Coupled Metal Ion Transporter

Mechanisms of Iron Transport in and out of Cells: Role of Ceruloplasmin

HFE

Melanotransferrin

References

IRON-RESPONSIVE ELEMENTS AND IRON REGULATORY PROTEINS

Introduction: The Discovery of Iron Responsive Elements (IRE) and Iron Regulatory Proteins (IRP)

Secondary and Tertiary Structures of IRE

Iron Regulatory Proteins

Role of IRP in Mediating Transferrin mRNA Stability

Role of IRP in the Control of Ferritin Translation

Evolution of IRPs

Regulation of IRP Activity by Nitric Oxide

Regulation of IRP by Oxidative Stress

Role of Phosphorylation in the Control of IRP Activity

Role of Heme in the Regulation of IRP Activity

IRPs Coordinate In Vivo Iron Metabolism

Tissue-Dependent Regulation of IRP Activity

Conclusions

References

FERRITIN

Introduction

Evolution of Ferritins

Three-Dimensional Structure of Ferritin

Ferroxidase Activity of Ferritin

Role of Phosphate on Iron Oxidation and Iron-Core Formation

Iron Release from Ferritin

Hemosiderin

Serum Ferritin

Ferritin Genes

Transcriptional Control of Ferritin Gene Expression

Ferritin and Endothelium

Ferritin in Tumor Cells

Ferritin Expression and Function in Selected Tissues

Unexpected Functions of Ferritin

References

INDEX

Subject Categories

BISAC Subject Codes/Headings:
MED005000
MEDICAL / Anatomy
MED038000
MEDICAL / Hematology
SCI017000
SCIENCE / Life Sciences / Cytology