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CRC Press
608 pages | 60 B/W Illus.
Proteins of Iron Metabolism presents a clear picture of the structure and function of the main proteins involved in iron metabolism. The book gives you a detailed description of the structure and function of each protein, and discusses the structure and regulation of the corresponding genes in parallel. It supplies an analysis of the differential expression and regulation of these proteins.
Numerous figures offer an integrated view of iron metabolism at the level of various tissues. The book delineates the mechanisms controlling cellular iron metabolism and shows how these mechanisms adapt to the differential and peculiar iron need of different cell types. Each chapter contains extensive bibliographical information providing a wide reference to the literature.
The comprehensive coverage of the advances in understanding the mechanisms controlling cellular iron metabolism, especially at the molecular level, found in this book will give you insight into the regulation of iron metabolism. Proteins of Iron Metabolism fills the need for a clearly written, comprehensive review of the latest research, putting every thing you need in one easy-to-use resource.
"This very comprehensive and well-integrated book, written by a single author, explores all of these issues with authority and in great depth. …The references are extensive and the index is good. …a valuable reference on a topic of major importance."
- Food and Nutrition Bulletin, 2002, The United Nations
IRON ABSORPTION
Introduction
Iron Requirements
Iron Digestion
Iron Absorption
Physiologic Regulation of Iron Absorption
Iron Bioavailability
Absorption of Heme Iron
References
IRON AND CELL PROLIFERATION: MECHANISMS AND APPLICATIONS IN CANCER THERAPY
Introduction
Ribonucleotide Reductase: A Key Enzyme in the Control of DNA Synthesis
Iron and Cell Cycle Control
Inhibition of Cell Proliferation by Agents that Reduce Cellular Iron Incorporation
Iron and Cancer
References
LACTOFERRIN
Introduction
Biochemistry and Molecular Biology of Lactoferrin
Lactoferrin Receptors
Functions of Lactoferrin
Lactoferrin Expression in Neutrophils and Mammary Glands
Lactoferrin Expression during Development
References
TRANSFERRIN
Introduction
Comparative Analysis of the Structures of Transferrin Family Proteins
Transferrin Genetic Variants
Biochemical Properties of Serum Transferrin
Transferrin Gene Expression
Transferrin and Microbiology
Transferrin as a Growth Factor
Congenital Atransferrinemia
Transferrin as a Transporter of Drugs
References
TRANSFERRIN RECEPTOR
Introduction
General Features
Molecular Biology
Transferrin Receptor Glycosylation
Trandferrin Receptor Endocytosis
Transferrin Receptor Phosphorylation
Intracellular Pools of Transferrin Receptors
Effect of Ca2+ and Oxidation on Transferrin Receptor Internalization
Tissue Distribution and Expression on Selected Cell Types
Regulation of Transferrin Receptors
Expression and Regulation in Different Cell Types
Interaction between Transferrin Receptors and HFE: The Class I MHC-Related Protein Mutated in Hereditary Hemochromatosis
A General Overview of Iron Uptake Mechanisms in Various Cell Types
References
SOLUBLE TRANSFERRIN RECEPTOR
Introduction
Generation of Soluble Transferrin Receptor
Circulation in Human Serum
Clinical Relevance
References
ALTERNATIVE IRON UPTAKE SYSTEMS
Transferrin-Idependent Iron Uptake
Proton-Coupled Metal Ion Transporter
Mechanisms of Iron Transport in and out of Cells: Role of Ceruloplasmin
HFE
Melanotransferrin
References
IRON-RESPONSIVE ELEMENTS AND IRON REGULATORY PROTEINS
Introduction: The Discovery of Iron Responsive Elements (IRE) and Iron Regulatory Proteins (IRP)
Secondary and Tertiary Structures of IRE
Iron Regulatory Proteins
Role of IRP in Mediating Transferrin mRNA Stability
Role of IRP in the Control of Ferritin Translation
Evolution of IRPs
Regulation of IRP Activity by Nitric Oxide
Regulation of IRP by Oxidative Stress
Role of Phosphorylation in the Control of IRP Activity
Role of Heme in the Regulation of IRP Activity
IRPs Coordinate In Vivo Iron Metabolism
Tissue-Dependent Regulation of IRP Activity
Conclusions
References
FERRITIN
Introduction
Evolution of Ferritins
Three-Dimensional Structure of Ferritin
Ferroxidase Activity of Ferritin
Role of Phosphate on Iron Oxidation and Iron-Core Formation
Iron Release from Ferritin
Hemosiderin
Serum Ferritin
Ferritin Genes
Transcriptional Control of Ferritin Gene Expression
Ferritin and Endothelium
Ferritin in Tumor Cells
Ferritin Expression and Function in Selected Tissues
Unexpected Functions of Ferritin
References
INDEX
