758 pages | 282 B/W Illus.
Expanding on the highly successful first edition, this second edition of Proton Therapy Physics has been completely restructured and updated throughout, and includes several new chapters. Suitable for both newcomers in medical physics and more seasoned specialists in radiation oncology, this book provides an in-depth overview of the physics of this radiation therapy modality, eliminating the need to dig through information scattered across medical physics literature.
After tracing the history of proton therapy, the book explores the atomic and nuclear physics background necessary for understanding proton interactions with tissue. The text then covers dosimetry, including beam delivery, shielding aspects, computer simulations, detector systems and measuring techniques for reference dosimetry. Important for daily operations, acceptance testing, commissioning, quality assurance and monitor unit calibrations are outlined. The book moves on to discussions of treatment planning for single- and multiple-field uniform doses, dose calculation concepts and algorithms, and precision and uncertainties for nonmoving and moving targets. Imaging for treatment guidance as well as treatment monitoring is outlined. Finally, the biological implications of using protons from a physics perspective are discussed.
This book is an ideal practical guide for physicians, dosimetrists, radiation therapists, and physicists who already have some experience in radiation oncology. It is also an invaluable reference for graduate students in medical physics programs, physicians in their last year of medical school or residency, and those considering a career in medical physics.
"Proton Therapy Physics" should be a must-have reference book on desks of all research and clinical physicists working in the field of proton therapy. The book is very comprehensive, covering all important aspects of proton therapy physics, including beam delivery, dosimetry, operation, treatment planning, image guidance, and biological efforts. Almost all chapter authors are well known experts in the field. So the chapters are all well written, informative, and up-to-date. More importantly, the editor, Dr. Harald Paganetti is a well-respected, well established researcher in proton therapy physics. I would strongly recommend this book!
— Steve B. Jiang, Professor Vice Chair, University of Texas Southwestern Medical Center
"Proton Therapy Physics is a comprehensive collection of outstanding chapters on the subject matter. The second edition is a necessary and welcome update of the first edition in this rapidly evolving field. It is edited by Prof. Harald Paganetti, an internationally renowned expert in the physics of proton therapy. It is difficult imagine a more qualified individual than Dr. Paganetti, with his in-depth understanding of physics and biology of protons, to produce such an impressive book. In addition to writing or contributing to four of the chapters himself, he has assembled a team of the well-known experts from all over the world to author the remaining nineteen chapters.
The book covers a full range of topics including physics of interactions of protons with matter, design and characteristics of passively-scattered and scanning proton therapy delivery systems, radiation shielding, relative and absolute dosimetry, commissioning and acceptance testing, dose calculations, design and optimization of treatment plans, imaging for proton range determination, uncertainties in planning and delivery of proton therapy and their management, biological effectiveness of protons, and more. Topics are dealt with in appropriate depth and supplemented with thousands of references for those interested in learning more. The book will serve as an excellent resource for students, trainees, radiation dosimetrists, radiation physicists and radiation oncologists. It will be equally valuable to new entrants in the field and for the experts, both clinical and research, interested in refreshing their knowledge.
The true potential of proton therapy to improve outcomes is yet to be realized. There are significant gaps in our understanding of physical and biological aspects of proton therapy and there are limitations of current techniques and technologies. Current research and technological advances are aimed at overcoming these gaps and limitations. Considering how rapidly the field of proton therapy is changing, I hope Dr. Paganetti and his team of contributors will again produce the next edition in a few years."
— Professor Radhe Mohan, MD Anderson Cancer Center, Houston, Texas
Chapter 1. Proton Therapy: History and Rational
Chapter 2. Physics of Proton Interactions in Matter
Chapter 3. Proton Accelerators
Chapter 4. Characteristics of Clinical Proton Beams
Hsiao-Ming and Jacob Flanz
Chapter 5. Beam Delivery Using Passive Scattering
Chapter 6. Particle Beam Scanning
Chapter 7. Secondary Radiation Production and Shielding at Proton Therapy Facilities
Nisy Elizabeth Ipe
Chapter 8. Monte Carlo Simulations
Chapter 9. Detectors, Relative Dosimetry, and Microdosimetry
Chapter 10. Absolute and Reference Dosimetry
Chapter 11. Acceptance Testing and Commissioning
Zuofeng Li, Roelf Slopsema, Stella Flamp ouri, and Daniel K. Yeung
Chapter 12. Quality Assurance
Chapter 13. Monitor Unit Calibration
Timothy C. Zhu, Haibo Lin, and Jiajian Shen
Chapter 14. Dose Calculation Algorithms
Ben Clasie, Harald Paganetti, and Hanne M. Kooy
Chapter 15. Physics of Treatment Planning for Single-Field Uniform Dose
Martij n Engelsman and Lei Dong
Chapter 16. Physics of Treatment Planning Using Scanned Beams
Chapter 17. Precision and Uncertainties in Planning and Delivery
Daniel K. Yeung and Jatinder R. Palta
Chapter 18. Precision and Uncertainties for Moving Targets
Christoph Bert, Martij n Engelsman, and Antje C. Knopf
Chapter 19. Treatment-Planning Optimization
Alexei V. Trofim ov, Davi d Craft, and Jan Unkelbach
Chapter 20. Proton Image Guidance
Chapter 21. In Vivo Dose Verification
Chapter 22. The Physics of Proton Biology
Chapter 23. Fully Exploiting the Benefits of Protons: Using Risk Models for Normal Tissue Complications in Treatment Optimization
Peter van Luijk and Marco Schippers