Pulmonary Nanomedicine: Diagnostics, Imaging, and Therapeutics, 1st Edition (Hardback) book cover

Pulmonary Nanomedicine

Diagnostics, Imaging, and Therapeutics, 1st Edition

Edited by Neeraj Vij

Jenny Stanford Publishing

300 pages | 14 Color Illus. | 10 B/W Illus.

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pub: 2012-08-06
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Description

This book explores engineered nanomaterials (ENM) pulmonary effects and familiarizes readers with unique aspects of nanomaterial application and research. Focusing on the diagnostic and therapeutic utilities of nanomaterials in different lung diseases, it discusses the novel applications of nanotechnology for the treatment of airway diseases such as asthma, allergy, chronic obstructive pulmonary diseases, cystic fibrosis, and lung cancer. In an attempt to synchronize the efforts of pulmonary biologists, chemists, and clinicians in developing novel nano-based tools for airway diseases, the book also discusses the strategies to overcome the pathophysiological and technical barriers.

Reviews

"Pulmonary Nanomedicine presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases. It describes numerous drug delivery, gene delivery, and theragnostic approaches for managing pulmonary disease outcomes. The book’s editor, Dr. Neeraj Vij, is an expert in pulmonary medicine and has done an excellent job in producing a high-class textbook."

—Prof. Rajiv R. Mohan - University of Missouri—Columbia, USA

"This book is a comprehensive treatise on emerging nanotechnology applications in the diagnosis and treatment of pulmonary diseases. It beautifully presents new drug delivery, gene delivery, and theragnostic approaches to improve pulmonary disease outcomes."

—Prof. Uday B. Kompella - University of Colorado, USA

Table of Contents

Contributors

Preface

Acknowledgments

Theranostic Applications of Nanotechnology in Chronic Obstructive Lung Diseases Neeraj Vij and Aakruti Gorde

Pulmonary Physiology and Pathogenesis of Chronic Obstructive Lung Diseases

Application of Nano-Based Systems in Treating Chronic Obstructive Lung Diseases

Nanotheranostics

Multifunctional Tumor-Targeted Nanoparticles for Lung Cancer Shinji Kuroda, Tomohisa Yokoyama, Justina O. Tam, Ailing W. Scott, Li Leo Ma, Manish Shanker, Jiankang Jin, Corbin Goerlich, David Willcutts, Jack A. Roth, Konstantin Sokolov, Keith P. Johnston, and Rajagopal Ramesha

Introduction

Biomarkers for Tumor Targeting

Nanotechnology in Medicine

EGFR-Targeted Hybrid Plasmonic Magnetic Multifunctional Nanoparticles

Conclusions

Nasal and Pulmonary Delivery of Macromolecules to Treat Respiratory and Nonrespiratory Diseases Durga Paturi, Mitesh Patel, Ranjana Mitra, and Ashim K. Mitra

Introduction

Nasal Drug Delivery

Pulmonary Drug Delivery

Conclusions

In vitro and in vivo Diagnosis of Pulmonary Disorders Using Nanotechnology Indrajit Roy

Introduction

Nanoparticles

In vitro Diagnosis, Techniques, and Challenges

In vivo Diagnosis, Challenges, and Techniques

1 ALI/ARDS

Toxicological Studies Using Nanoparticles

Conclusions

Nanoparticles for Targeting T Cells in Allergy and Inflammatory Airway Conditions Adham Bear, Laura B. Carpin, Conrad R. Cruz, Rebekah A. Drezek, and Aaron E. Foster

Introduction

Role of T Cells in the Pathogenesis of Asthma

Treatment Strategies for Asthma

Potential T Cell–Targeted Strategies for Nanoparticle-Based Therapies

T Cell-Targeting Ligands

Alternative Approaches

Summary

Multifunctional Chitosan Nanocarriers for Respiratory Disease Gene Therapy Shyam S. Mohapatra, Subhra Mohapatra, Gary Hellermann, and Rhonda R. Wilbur

Introduction

Therapeutic Effects and Safety of Chitosan in Human Disease

Safety and Efficacy Studies in Dogs

Safety of Chitosan-Gene Nanocomplexes in Nonhuman Primates

Respiratory Disease Applications

Future of Immunotherapy

Concluding Remarks

Targeted Delivery to the Pulmonary Endothelium Yifei Zhang, Jiang Li, Xiang Gao, and Song Li

Introduction

Pulmonary Endothelium as a Target for Drug Delivery

Targeting the Pulmonary Endothelium for Imaging and Therapeutic Applications

Conclusion

Nanosystems for Selective Epithelial Barrier Targeting in Chronic Airway Diseases Heather A. Parsons, Rachel L. Damico, and Venkataramana K. Sidhaye

Introduction

Obstructive Lung Diseases

NP Delivery of Airway Diseases

Toxicity of NPs

Conclusions and Future Directions

Potential Respiratory Health Risks of Engineered Carbon Nanotubes James C. Bonner, Jeffrey W. Card, Stavros Garantziotis, and Darryl C. Zeldin

Introduction

Immune Cell Interaction with CNTs

Fibrogenic Reactions to CNTs

CNTs and Preexisting Allergic Asthma

CNTs and LPS-Induced Airway Inflammation

Effects of CNTs on Other Organ Systems

DNA Damage and Aneuploidy Caused by CNTs

Pleural Toxicity of CNTs

Conclusions

Subject Categories

BISAC Subject Codes/Headings:
MED009000
MEDICAL / Biotechnology
MED079000
MEDICAL / Pulmonary & Thoracic Medicine