This work focuses on several approaches to modulated control release systems, including polymers responding to external stimuli (pH glucose concentration), polymer drug-magnetic and ultrasonic systems. This book is aimed at the next generation of drug delivery systemsópumps that can be activated to provide different rates, polymers responding to pH stimuli, non-erodible polymers containing enzymes that cause the polymer to swell and regulate the rate of delivery in response to external stimuli, lectin drug systems that release additional drug due to the affinity of an external molecule for the lectin, and release of vesicle-entrapped substances in response to changes in environmental conditions. This reference shows that drug delivery patterns can be further optimized by pulse or self-regulated delivery, adjusted to the staging of biological rhythms.
Written in a systematic format, this book is a useful resource for those involved with pharmaceutical sciences, biomedical materials research, chemistry, macromolecules, and chemical engineering.
PREFACE. EXTERNAL PULSED DELIVERY. Magnetically and Ultrasonically Modulated Drug Delivery Systems. Temperature Responsive Controlled Drug Delivery. Electrically and Mechanically Controlled Hydrogels for Drug Delivery. Iontophoretic Transport of Drugs: A Constant Voltage Approach. SELF REGULATED DELIVERY. Use of Enzymes and Bioerodible Polymers in Self-Regulated and Triggered Drug Delivery Systems. Environmentally-Sensitive Vesicles for Controlled Drug Delivery. The Self-Regulated Delivery of Chelating Agents. pH Sensitive Gels: Swelling Equilibria, Kinetics and Applications for Drug Delivery. Glucose Sensitive Membranes for Controlled Release of Insulin. A Self-Regulating Insulin Delivery System Based on Competitive Binding of Glucose and Glycosolated Insulin. Solubility Dependent Controlled Release Systems.