1st Edition

Quantitative MRI in Cancer

ISBN 9781439820575
Published September 13, 2011 by CRC Press
344 Pages - 13 Color & 141 B/W Illustrations

USD $190.00

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Book Description

Propelling quantitative MRI techniques from bench to bedside, Quantitative MRI in Cancer presents a range of quantitative MRI methods for assessing tumor biology. It includes biophysical and theoretical explanations of the most relevant MRI techniques as well as examples of these techniques in cancer applications.

The introductory part of the book covers basic cancer biology, theoretical aspects of NMR/MRI physics, and the hardware required to form MR images. Forming the core of the book, the next three parts illustrate how to characterize tissue properties with endogenous and exogenous contrast mechanisms and discuss common image processing techniques relevant for cancer. The final part explores emerging areas of MR cancer characterization, including radiation therapy planning, cellular and molecular imaging, pH imaging, and hyperpolarized MR. Each of the post-introductory chapters describes the salient qualitative and quantitative aspects of the techniques before proceeding to preclinical and clinical applications. Each chapter also contains references for further study.

Leading the way toward more personalized medicine, this text brings together existing and emerging quantitative MRI techniques for assessing cancer. It provides a self-contained overview of the theoretical and experimental essentials and state of the art in cancer MRI.

Table of Contents

Physical Basis of Magnetic Resonance Imaging
The Biology and Imaging of Cancer, Michelle D. Martin and J. Oliver McIntyre
Physics of MRI, Seth A. Smith
MRI: Hardware and Data Acquisition, E. Brian Welch
Image Formation, David R. Pickens

Characterizing Tissue Properties with Endogenous Contrast Mechanisms
Quantitative Measurement of T1, T2, T2*, and Proton Density, Richard D. Dortch and Mark D. Does
Arterial Spin Labeling Techniques, Bruce M. Damon and Christopher P. Elder
Diffusion-Weighted MRI, Lori R. Arlinghaus and Thomas E. Yankeelov
Magnetization Transfer and Chemical Exchange Saturation Transfer Imaging in Cancer Imaging, Daniel F. Gochberg and Martin Lepage
MR Spectroscopy and Spectroscopic Imaging of Tumor Physiology and Metabolism, Marie-France Penet, Dmitri Artemov, Noriko Mori, and Zaver M. Bhujwalla

Characterizing Tissue Properties with Exogenous Contrast Agents
Contrast Agents for T1-Weighted MRI, Jason R. Buck, Matthew R. Hight, Dewei Tang, and H. Charles Manning
Nanoparticles for T2 and T2*-Weighted MRI, Michael Nickels and Wellington Pham
Dynamic Contrast-Enhanced MRI: Data Acquisition and Analysis, Mary E. Loveless and Thomas E. Yankeelov
Dynamic Susceptibility MRI: Data Acquisition and Analysis, C. Chad Quarles
Magnetic Resonance Angiography, Ronald R. Price, Ronald C. Arildsen, and Jeffrey L. Creasy

Image Processing in Cancer
Imaging Tissue Oxygenation Status with MRI, Nilesh Mistry and C. Chad Quarles
Clinical Assessment of the Response of Tumors to Treatment with MRI, Mia Levy
Image Segmentation, Shaun S. Gleason, Vincent C. Paquit, and Deniz Aykac
Spatial and Temporal Image Registration, Xia Li
Synthesis of Multiparametric Data, Kathryn M. McMillan, C. Chad Quarles, and Ronald R. Price

Emerging Trends
MRI in Radiation Therapy Planning, George X. Ding, Eddy S. Yang, Ken J. Niermann, Fen Xia, and Anthony Cmelak
Molecular and Cellular Imaging, Martin Lepage
Hyperpolarized MR of Cancer, Kevin W. Waddell and Eduard Y. Chekmenev


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Thomas E. Yankeelov is the director of Cancer Imaging Research at the Vanderbilt University Institute of Imaging Science. He is also an associate professor of radiology and radiological sciences, physics and astronomy, biomedical engineering, and cancer biology at Vanderbilt University.

David R. Pickens is an associate professor of radiology and radiological sciences at the Vanderbilt University School of Medicine.

Ronald R. Price is a professor of radiology and radiological sciences as well as physics and astronomy at Vanderbilt University.


"… this book fills a void in the literature in this area. … The text is well written and in particular is well organized … The text has abundant mathematic derivations and numerous figures and diagrams (including many pulse sequence diagrams) … the text fulfills the goal of providing a one-volume overview of quantitative oncologic MR imaging. It is ideally suited to physician scientists and medical physicists working to advance research in the field and improve future clinical MR imaging applications."
—Michael Orsi, Radiology, July 2012

"This book presents a range of quantitative MRI methods for assessing tumor biology, including biophysical and theoretic explanation of the most relevant MRI techniques as well as examples of these techniques in cancer applications. … I recommend this special book to trainees and radiologists using advanced MRI and to basic scientists and physician scientists using MRI."
—E. Edmund Kim, Journal of Nuclear Medicine, June 2012

"… useful as an introductory text for imaging scientists and physicians who engage in quantitative cancer imaging methodologies with other modalities, such as nuclear medicine. … the greatest strengths of this book are its breadth of subject matter, the uniformly large numbers of citations provided by the chapter authors and the detailed index."
—Geoffrey Clarke, Medical Physics, March 2012