2nd Edition

Quantitative MRI of the Brain
Principles of Physical Measurement, Second edition

ISBN 9781138032859
Published January 26, 2018 by CRC Press
342 Pages 139 Color Illustrations

USD $195.00

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Book Description

Building on the success of the first edition of this book, the winner of the 2004 British Medical Association Radiology Medical Book Competition, Quantitative MRI of the Brain: Principles of Physical Measurement gives a unique view on how to use an MRI machine in a new way. Used as a scientific instrument it can make measurements of a myriad of physical and biological quantities in the human brain and body. For each small tissue voxel, non-invasive information monitors how tissue changes with disease and responds to treatment.

The book opens with a detailed exposition of the principles of good practice in quantification, including fundamental concepts, quality assurance, MR data collection and analysis and improved study statistical power through minimised instrumental variation. There follow chapters on 14 specific groups of quantities: proton density, T1, T2, T2*, diffusion, advanced diffusion, magnetisation transfer, CEST, 1H and multi-nuclear spectroscopy, DCE-MRI, quantitative fMRI, arterial spin-labelling and image analysis, and finally a chapter on the future of quantification. The physical principles behind each quantity are stated, followed by its biological significance. Practical techniques for measurement are given, along with pitfalls and examples of clinical applications.

This second edition of this indispensable 'how to' manual of quantitative MR shows the MRI physicist and research clinician how to implement these techniques on an MRI scanner to understand more about the biological processes in the patient and physiological changes in healthy controls. Although focussed on the brain, most techniques are applicable to characterising tissue in the whole body.

This book is essential reading for anyone who wants to use the gamut of modern quantitative MRI methods to measure the effects of disease, its progression, and its response to treatment.


  • The first edition was awarded the book prize for Radiology by the British Medical Association in 2004
  • Written by an authority in the field: Professor Tofts has an international reputation for quantification in MRI
  • Gives specific ‘how to’ information for implementation of MRI measurement sequence techniques

Table of Contents

Concepts: Measurement in MRI

Measurement Process: MR Data Collection and Image Analysis

Quality Assurance: Accuracy, Precision, Controls and Phantoms

PD: Proton Density of Tissue Water

T1: Longitudinal Relaxation Time

T2: Transverse Relaxation Time

T2*: Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping

D: The Diffusion of Water (DTI)

Advanced Diffusion Models

MT: Magnetisation Transfer

CEST: Chemical Exchange Saturation Transfer

MRS: 1H Spectroscopy

Multinuclear MR Imaging and Spectroscopy

 T1-Weighted DCE MRI

Functional and Metabolic MRI

ASL: Blood Perfusion Measurement Using Arterial Spin Labelling

Image Analysis

Future of Quantitative MRI

Appendix A: Greek Alphabet for Scientific Use

Appendix B: MRI Abbreviations and Acronyms

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Professor Mara Cercignani, Chair in Medical Physics at Brighton and Sussex Medical School, University of Sussex.

Dr Nicholas Dowell, Lecturer in Imaging Physics, Brighton and Sussex Medical School, University of Sussex.

Professor Paul Tofts, Emeritus professor, Brighton and Sussex Medical School, University of Sussex.

Featured Author Profiles

Author - Nicholas G Dowell

Nicholas G Dowell

Lecturer in Imaging Physics, Brighton and Sussex Medical School

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"Upon its release in 2003, Paul Tofts’ 'Quantitative MRI of the Brain' instantly became a classic among MR textbooks as it comprised the up-to-then knowledge on quantitation using MRI. Now, more than a decade later, it was due time for an update on this rapidly developing field, and the second edition by Cercignani, Dowell, and Tofts will surely become as popular.
The chapters are written by international experts in the field cover the whole scope of qMRI techniques to study the human brain. The extended chapter on quality assurance is particularly instructive to medical physics experts.
The chapters on the philosophical groundwork of the principles of physical measurement have been thoroughly extended, making it a must read for students entering the field of qMRI and an inspiration for reflections of senior researchers. I am using the second edition extensively for teaching students."
Dr. Gunther Helms, Senior lecturer, Swedish National 7T Facility, Lund University, Sweden

"'Quantitative MRI of the Brain', edited by Cercignani, Dowell and Tofts, is a comprehensive and authoritative reference for this important area of research, which is rapidly developing with novel scanning techniques and increasing interest in microstructure imaging.
The book provides an accessible introduction for those new to the field, while offering advanced readers sufficient detail on the broad variety of quantification approaches in anatomical and physiological imaging. The discussion of each quantitative parameter and technique is well balanced to cover theory, technical aspects, biological interpretation, and applications. This second edition of 'Quantitative MRI of the Brain', a substantial and timely revision, promises to become a classic as its predecessor already is."
Prof. Dr. Nikolaus Weiskopf, Director of Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Germany