174 pages | 32 B/W Illus.
Gene expression in eukaryotes is regulated at different levels, which need to be coordinated to implement the information in the genome. Now it is clear that post-transcriptional regulation of gene expression such as pre-mRNA splicing, mRNA transport, editing, turnover and translation are as important as the control of transcription. In all aspects of post-transcriptional gene regulation a crucial role for RNA binding proteins (RBPs) has been documented. In fact, RNA polymerase II transcripts are accompanied by the RBPs from the start of the transcription until they are degraded in the cytoplasm. The contributing authors of this book provide informative and well-illustrated chapters, addressing different aspects of post-transcriptional regulation of gene expression and providing a stimulating overview of RBPs and their highly diverse and versatile function.
1. hnRNP and hnRNP-Like Proteins in Splicing Control: Molecular Mechanisms and Implication in Human Pathologies 2. The Role of SR and SR-Related Proteins in pre-mRNA Splicing 3. The Functions of Glycine-Rich Regions in TDP-43, FUS and Related RNA-Binding Proteins 4. Subcellular RNA Localization and Translational Control: Mechanisms and Biological Significance in the Vertebrate Nervous System 5. RNA-Binding Proteins in Fungi and Their Role in mRNA Localization 6. mRNA Localization in Plants and the Role of RNA Binding Proteins 7. RNA Binding Domains and RNA Recognition by RNA-Editing Machineries 8. RNA-Binding Proteins in Plant Response to Abiotic Stresses 9. From Structure to Function of RNA Binding Domains