Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology, 1st Edition (e-Book) book cover

Radiotherapy Treatment Planning

Linear-Quadratic Radiobiology, 1st Edition

By J. Donald Chapman

CRC Press

190 pages

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Hardback: 9781439862599
pub: 2015-04-16
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pub: 2016-04-21
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Description

Understand Quantitative Radiobiology from a Radiation Biophysics PerspectiveIn the field of radiobiology, the linear-quadratic (LQ) equation has become the standard for defining radiation-induced cell killing. Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology describes tumor cell inactivation from a radiation physics perspective and of

Table of Contents

Introduction. The Generation of Quantitative Radiobiology Data. Intrinsic Radiosensitivity of Proliferating and Quiescent Cells. Effects of Ionization Density and Volume. Impact of Fraction Size, Dose-Rate, Temperature and Overall Treatment Time on Tumor Cell Response. Ionizing Events, Molecular Targets and Lethal Lesions. The Radiosensitivity of Tumor Cells In Vitro versus In Vivo. Modern Radiobiology and the LQ Equation. Normal Tissues Radiobiology. Radiobiology Applied to Tumor Response Modeling. Epilogue. References. Index.

About the Author

J. Donald Chapman provides consulting services to various radiation medicine commercial and academic organizations. His research has contributed to the fields of hypoxic radiosensitizing drugs, nuclear medicine markers of viable hypoxic cells, mechanisms of photodynamic therapy, and the killing of tumor cells by ionizing radiations. He has authored and co-authored over 200 articles in scientific journals and conference proceedings, served on the editorial boards of numerous radiation research journals, and received several international research awards. He earned a PhD in biophysics from the Pennsylvania State University.

Alan E. Nahum is head of physics research at Clatterbridge Cancer Centre and a visiting professor in the Department of Physics at Liverpool University. His current research focuses on radiobiologically guided treatment optimization through the individualization of tumor prescription and fractionation. He has edited and co-edited three books, including Handbook of Radiotherapy Physics: Theory and Practice, and authored and co-authored approximately 170 peer-reviewed papers, book chapters, and conference proceedings. He earned a PhD in theoretical radiation dosimetry from the University of Edinburgh.

Subject Categories

BISAC Subject Codes/Headings:
MED062000
MEDICAL / Oncology
MED080000
MEDICAL / Radiology & Nuclear Medicine
SCI055000
SCIENCE / Physics