Common factors that lead to treatment failure in head and neck cancer are the lack of tumour oxygenation, the accelerated division of cancer cells during treatment, and radioresistance. These tumour-related challenges and possible ways to overcome them are covered in this book, authored by three medical physicists and a clinical oncologist who explain how different radiobiological findings have led to the development of various treatment techniques for head and neck cancer.
Novel treatment techniques as supported by current scientific evidence are comprehensively explored, as well as the major challenges that arise in the retreatment of patients who have already undergone a form of radiotherapy for primary head and neck cancer.
- Uses an interdisciplinary approach, encompassing clinical aspects of radiotherapy, radiation biology, and medical physics
- Applies content by relating all radiobiological characteristics to their respective clinical implications
- Explains the radiobiological rationale for all previous and current clinical trials for head and neck cancer
Table of Contents
Preface. Introduction. Chapter 1. Introductory aspects of head and neck cancers. Chapter 2. Clinical aspects of head and neck cancer. Chapter 3. General radiobiology refresher. Chapter 4. Hypoxia and angiogenesis. Chapter 5. The mechanisms behind tumour repopulation. Chapter 6. The radiobiology of HPV-associated head and neck cancer. Chapter 7. Normal tissue tolerance. Chapter 8. The treatment of head and neck cancer. Chapter 9. Targeted therapies. Chapter 10. Retreatment issues. Appendix: Radiobiological modelling.
Loredana Marcu is Professor of Medical Physics at the University of Oradea, Romania, and Adjunct Professor at School of Health Sciences, University of South Australia.
Iuliana Toma-Dasu is Associate Professor in Medical Radiation Physics in the Department of Physics, Stockholm University, and she is the research group leader of the Stockholm University Medical Radiation Physics division, which is affiliated with the Department of Oncology and Pathology at the Karolinska Institutet.
Alexandru Dasu is the Chief Medical Physicist at the Skandion Clinic, the national Swedish proton centre in Uppsala and Associate Professor in Medical Radiation Physics.
Claes Mercke is Professor of Radiation Oncology and one of the senior physicians at the Karolinska University Hospital, Department of Oncology, in Stockholm, Sweden.