First Published in 1982, this book explores the role of receptor-binding radiotracers. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of radiology, and other practitioners in their respective fields.
SECTION I: BIOCHEMICAL BASIS FOR RECEPTOR-BINDING RADIOTRACERS.
Introduction. 1. Receptor Binding Studies: General Considerations. 2. Identification of Receptors In Vitro. 3. Localizing Drug and Neurotransmitter Receptors in Vivo with Tritium-Labeled Tracers.
SECTION II: RADIOPHARMACEUTICAL CHEMISTRY OF RECEPTOR-BINDING RADIOTRACERS.
Introduction. 4. Production of High Specific Activity Compounds with Short-Lived Radionuclides. 5. Radiolabeled Adrenergic and Musearinic Blockers for In Vivo Studies. 6. In Vivo and In Vitro Steroid Receptor Assays in the Design of Estrogen Radiopharmaceuticals. 7. Radiolabeled Enzyme Inhibitors. 8. Radioiodinated Cholesterol as a Radiotracer in Biochemical Studies. Index.
Introduction. 1. Application of Modeling Principles to Receptor-Binding Radiotracers. 2. Pharmacokinetic Aspects of the In vivo, Noninvasive Study of Neuroreceptors in Man. 3. A Complimentary Radiopharmaceutical and Mathematical Model by Pharmacokinetic Modeling. 4. Separating Changes in Flow from Changes in Receptor Binding by Pharmacokinetic Modeling.
SECTION IV: INSTRUMENTATION FOR RECEPTOR-BINDING RADIOTRACERS.
Introduction. 5. Simulated Uptake Ratio Requirements for Spherical Lesions Imaged with a Conventional Scintillation Camera. 6. Potential of Longitudinal Tomography for Imaging Receptor-Binding Radiotracers. 7. Emission Tomography-Detection of Single Photons with Multidetector Devices and Rotating Gamma Cameras. 8. Instrumentation for Quantitative Tomographic Determination of Concentrations of Positron-Emitting, Receptor-Binding Radiotracers.
SECTION V: CLINICL RELEVANCE OF RECEPTOR-BINDING RADIOTRACRES.
Introduction: The Role of Receptors in Disease. 9. Quantitative Changes in Receptor Concentrations as a Function of Disease. Index.
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