Regenerative Medicine Technology: On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine, 1st Edition (Hardback) book cover

Regenerative Medicine Technology

On-a-Chip Applications for Disease Modeling, Drug Discovery and Personalized Medicine, 1st Edition

Edited by Sean V. Murphy, Anthony Atala

CRC Press

428 pages | 45 Color Illus. | 5 B/W Illus.

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pub: 2016-12-13
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Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery.

This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.

Table of Contents


Microfabrication and 3-D Bioprinting of Organs-on-a-Chip

Prafulla Chandra, Carlos Kengla, Sang Jin Lee

Three-Dimensional Cell Culture

Ivy L. Mead, Colin E. Bishop

Electrochemical Sensors for Organs-on-a-Chip

Joyce Han-Ching Chiu, Ge-Ah Kim, Rodney Daniels


Panupong Jaipan, Roger Narayan

From Big Data to Predictive Analysis from in vitro Systems

Andre Kleensang, Alexandra Maertens, Thomas Hartung

Lab-on-a-Chip Systems for Biomedical Applications

Peter Ertl

From 2D Culture to 3D Microchip Models: Trachea, Bronchi/bronchiole and Lung Biomimetic Models for Disease Modeling, Drug Discovery and Personalized Medicine

Joan E. Nichols,Stephanie P. Vega,Lissenya B. Argueta, Jean A. Niles, Michael Smith, Adrienne Eastaway, David Brown, Joaquin Cortiella

Liver and Liver Cancer-on-a-Chip

Aleksander Skardal


Megan L. McCain


Claire G. Jeong

Tissue Engineered Kidney Models

Erica P. Kimmerling, David L. Kaplan


Mahesh Devarasetty, Steven D. Forsythe,Thomas D. Shupe, Aleksander Skardal, Shay Soker

Integrated Multi-Organoid Dynamics

Ran Li, Michelle B. Chen, Roger D. Kamm

Cancer Metastasis-on-a-Chip

Ran Li, Michelle B. Chen, Roger D. Kamm

Breast Cancer-on-a-Chip

Pierre-Alexandre Vidi, Sophie A. Lelièvre

Disease Modeling

Harry SalemUta Grieshammer, Kelly A. Shepard

In Vivo, In Vitro And Stem Cell Technologies To Predict Human Pharmacology and Toxicology

Harry Salem

Personalized Medicine

Elisa Cimetta, Michael Lamprecht, Sarindr Bhumiratana,Nafissa Yakubova,Nina Tandon

About the Series

Gene and Cell Therapy

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Biotechnology
MEDICAL / Oncology
SCIENCE / Life Sciences / Cytology
SCIENCE / Life Sciences / General