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Renal Cell Carcinoma: 1st Edition (Hardback) book cover

Renal Cell Carcinoma

1st Edition

By Eric A. Klein

CRC Press

368 pages

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Hardback: 9780824790332
pub: 1993-04-23
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This reference brings together all aspects of renal cell carcinoma, and provides a basis for understanding the disease's origin, progression and responses to immunotherapy.;Examining the current status of cytokine, cell-based and chemotherapeutic methods of treatment, this book: discusses the clinical presentation of advanced renal carcinoma and its therapeutic challenges; reviews prognostic factors and the management of renal cell carcinoma occurring with von Hippel-Landau syndrome; summarizes efforts to identify the tumour suppressor gene deleted from chromosome 3 in most renal cell carcinomas; explicates the role of oncogenes in the progression of renal cell cancer and the molecular correlates of responses to interferon-alpha treatment; details the latest laboratory efforts to establish gene therapy for tumour treatment by transfection of cytokine genes in murine model systems; focuses on biologic response modifier therapy in humans, including cell-mediated immune responses and adoptive immunotherapy; presents preclinical and clinical studies of interleukin-2 alone, in combination with othe cytokines, and with chemothrapeutic agents; and addresses studies on the tumour necrosis factor and low- and high-dose interferon-alpha.

Table of Contents

The challenge of advanced renal cell carcinoma; clinical features; molecular biology; cell-mediated immune responses and adoptive immunotherapy; interleukin-2 and other cytokines; combination therapy with cytokines; chemotheray and chemoimmunotherapy

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Nephrology
MEDICAL / Oncology