Reproductive Toxicology: 3rd Edition (Hardback) book cover

Reproductive Toxicology

3rd Edition

Edited by Robert W. Kapp, Rochelle W. Tyl

CRC Press

512 pages | 30 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9781420073430
pub: 2010-09-20
eBook (VitalSource) : 9780429146763
pub: 2016-04-19
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Thoroughly examining the popular and expanding field of reproductive toxicology, this newly revised and expanded third edition provides the latest, cutting-edge scientific developments in this constantly evolving discipline. Reproductive Toxicology’s contributors are experienced regulatory agency and Clinical Research Organization representatives who currently utilize the new techniques discussed in the text and continue to revolutionize reproductive toxicology research.

This ground-breaking resource includes:

  • New and important critical mechanistic topics such as epigenetics and omics
  • The first significant compilation of epigenetic mechanisms
  • An in-depth analysis of the role of genomics, proteomics, and metabolomicsin human reproduction
  • New guidelines with respect to the latest research applications in the field


"Due to the wealth of new information that we have gained over the last 15 years, a new edition is absolutely necessary to keep pace with the study of environmental substances and their effects on reproduction and development … This book easily leads the pack in the field of research toxicology. For those interested in keeping current in this field, it is a must-have. It is important to note that this book should be on the shelf of any physician-scientist studying the impact of environmental exposures on human health, reproduction, and development."

Doody's Review Service

"This new edition of the Target Organ Toxicology series is a welcome addition to the series and, as with the previous two editions, it has brought together the leading authorities in the field to provide an authoritative text on the increasingly important topic of reproductive toxicology. The breadth of the topics covered is truly impressive and while there is continuity with the previous two editions, this third edition covers areas which will undoubtedly be a surprise to some, as it was to this reviewer."

The British Toxicology Society Newsletter

Table of Contents

Normal reproduction and development

Biology and physiology of fertilization, John Parrish

Normal development of the male reproductive system, Reza J. Rasoulpour, M. Sue Marty, Kamin J. Johnson, and Edward W. Carney

Normal development of the female reproductive system, Jerome M. Goldman and Ralph L. Cooper

Development of the mammalian nervous system, Kimberly Ehman

Regulatory evaluation of reproduction

FDA and ICH perspectives on reproductive and developmental toxicology, Rochelle W. Tyl

EPA and OECD perspectives on reproductive and developmental toxicity testing, Susan L. Makris

Reproductive study evolution and IND submissions for the Food and Drug Administration, Robert W. Kapp, Jr.

Developmental toxicity of systemic organ systems

Developmental immunotoxicology, Mark Collinge, Leigh Ann Burns-Naas, and Thomas T. Kawabata

Developmental neurotoxicology, Merle G. Paule and William Slikker, Jr.

Developmental toxicology of the respiratory system, Raymond G. York and Robert M. Parker

Developmental toxicity of the kidney, Gregg D. Cappon and Mark E. Hurtt

Developmental toxicology of the liver, Kartik Shankar and Harihara M. Mehendale

Cardiovascular development and malformation, John M. DeSesso and Arthi G. Venkat

Toxicity of the reproductive process

Male reproductive toxicity, Robert W. Kapp, Jr.

Female reproductive toxicity, Ralph L. Cooper and Jerome M. Goldman

Toxicity of the pregnant female reproductive system, Mallikarjuna Basavarajappa, Jackye Peretz, Tessie Paulose, Rupesh Gupta, Ayelet Ziv-Gal, and Jodi A. Flaws

Epigenetic reproductive toxicants, Retha Newbold and Harriet Karimi Kinyamu

Cumulative effects of in utero administration to mixtures of reproductive toxicants in the male rat: a systems biology framework, L. Earl Gray, Jr., Cynthia V. Rider, Vickie S. Wilson, Kembra L. Howdeshell, Andrew K. Hotchkiss, Chad Blystone, Johnathan R. Furr, Christy R. Lambright, and Paul Foster

Metals and metal compounds in reproductive and developmental toxicology, Mari S. Golub

Omics in reproductive and developmental toxicology, Susan Sumner, Rodney Snyder, Jason Burgess, Timothy Fennell, and Rochelle W. Tyl


About the Series

Target Organ Toxicology Series

Learn more…

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Endocrinology & Metabolism
MEDICAL / Reproductive Medicine & Technology
MEDICAL / Toxicology