Progress in Research and Clinical Applications
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This volume contains papers presented at the Conference on Retinoids: New Trends in Research and Clinical Applications, held in 1991 in Palermo, Italy, describing the latest research findings on biochemistry, nutrition, molecular and cell biology and developmental biology, as well as the pharmacology and the therapeutic use of vitamin A and its congeners.;Written by leading authorities in the field from the USA, Europe and Japan, Retinoids, amongst other things: addresses retinol-supported retinoic acid (RA) synthesis and catabolism; identifies synthetic ligands with a high selective affinity for RAR-alpha, -beta and -gamma nuclear receptors, determining if they would show pharmacological properties similar to the natural parent substance all-trans RA; considers the embryonic/foetal cellular retinoid-binding proteins and evidence for their participation in normal and abnormal morphogenesis; discusses a novel arotinoid, Ro 40-8757, that exhibited improved anti-tumour efficacy and safety in pre-clinical tests; and reports the audioradiographic distribution of retinol and RA in organs of pregnant hamsters and foetuses.
Table of Contents
Part 1 Metabolism and nutrition: conversion of carotenoids to retinoids, Norman I. Krinsky, et al; interactions of retinoids with lipid bilayers and with membranes, Noa Noy; roles of cellular retinol-binding protein and cellular retinoic acid-binding protein in the metabolic channeling of retinoids, J.S. Napoli, et al; molecular mechanisms of accumulation of retinoids in adult and embryonic cells, Claes-Olof Bavik, et al; retinoids are actively metabolized in rabbit bone marrow, William S. Blaner, et al; retinol-binding protein expression and its regulation in adipose tissue, DeWitt S. Goodman, et al; plasma retinol-binding protein and its interaction with transthyretin, Rodolfo Berni, et al; role of fatty acid-binding protein as a vehicle of retinoids, Fumio Fukai and Takashi Katayama; vitamin A-binding proteins in the cells of rat seminiferous tubules, Michela Galdieri, Raffaella Faraonio, and Vittorio Colantuoni; retinol-binding protein expression and its regulation in liver and cultured cell lines, Marie-Sophie Mourey, et al; enzymatic synthesis of retinoic acid in retin, John C. Saari and Gregory G. Garwin; retinol-binding proteins and the All-transto 11-CIS isomerization of retinol in the pigment epithelium, Maria A. Livrea, et al; the epidemiology of vitamin A deficiency and depletion (hypovitaminosis A) as a public health problem, Barbara A. Underwood; model-based compartmental analysis of retinol kinetic in organs of rats as different levels of vitamin A Status, Michael H. Green, et al. Part 2 Molecular and cell biology: interaction of retinoids with retinoic acid nuclear receptor isoforms, Marcia I. Dawson, et al; retinoic acid receptors and the regulation of gene expression in tracheobronchial epithelial cells, Anton M. Jetten, et al; binding affinities of retinoids to their binding protein receptors and their biological activities, Brahma P. Sani; differential expression of cytoplasmic retinoic acid-binding proteins I and II mRNA and proteins in normal and psoriatic human skin, Georges Seigenthaler, et al; selective synthetic ligands for nuclear retinoic acid receptor subtypes, Braham Shroot, et al; identification of thymosin Beta-10 as a developmentally regulated, retinoid-responsive gene expressed in malignant tumours and embryoinic tissues, Alan K. Hall; retinoic status, skin tumour formation, and differentiation, Luigi M. De Luca, et al; modulation of cell proliferation and differentiation by retinoids, cytokines, and their combination - experimental and clinical aspects, Werner Bollag and Richard Peck. Part contents.
". . .an outstanding book, current in its information, extensive in the contributions from many of the leading researchers, and very well organized and indexed. "
---Journal of Optimal Nutrition