1st Edition
Retinoids in Dermatology
Retinoids are valuable drugs in the dermatologic armamentarium, being employed in daily clinical practice. The text provides an in-depth update on the latest thinking on pharmacology, clinical use, side effects, and follow-up of retinoid therapy in dermatology; it also addresses topics related to retinoid use in special circumstances, such as vulnerable populations, concomitant surgery, and aesthetic procedures.
CONTENTS: The background of retinoids * Mechanism of action of vitamin A * Mechanism of action of topical retinoids * Mechanism of action of isotretinoin * Mechanism of action of acitretin * Mechanism of action of bexarotene * Mechanism of action of alitretinoin * Effects of retinoids at the cellular level (differentiation, apoptosis, autophagy, cell cycle regulation, and senescence) * Effects of retinoids at the systemic level * New aspects of isotretinoin teratogenicity * Mucocutaneous side effects * Ophthalmologic side effects * Musculoskeletal side effects * Neurologic side effects * Psychiatric side effects * Gastrointestinal side effects * Endocrine and metabolic side effecs * Other systemic side effects: Cardiovascular, pulmonary, otolaryngorhinologic, genitourinary, renal, and immunologic * Retinoids in acne * Retinoids in hidradenitis suppurativa/acne inversa * Retinoids in rosacea * Retinoids in hair disorders * Retinoids in psoriasis * Retinoids in keratinization disorders * Retinoids in antiaging therapy * Retinoids in other skin diseases * Retinoids in lymphoma * Retinoids in cutaneous chemoprophylaxis * Guide to good clinical practice for vulnerable populations (infancy, childhood, fertile period, elderly) * Retinoids and concomitant surgery * Retinoids and concomitant aesthetic procedures * Laboratory and clinical follow-up * Teratogenicity and registry programs * Management of vitamin A and retinoid side effects * Future and novel unexplored indications of retinoids
Published in association with the Journal of Dermatological Treatment.
1 Introduction and historical background
Ayse Serap Karadag, Berna Aksoy, and Lawrence C Parish
2 Mechanism of action of Vitamin A
Sandra Maria Barbalho
3 Mechanism of action of topical retinoids
Sümeyre Seda Ertekin and Mehmet Salih Gurel
4 Mechanism of action of isotretinoin
Bodo Melnik
5 Mechanism of action of acitretin
Kaitlyn Lam and Ronald Vender
6 Mechanism of action of bexarotene
Catherine M Ludwig, Claire Wilson, Brandon Roman, and Maria M Tsoukas
7 Mechanism of action of alitretinoin
Ömer Faruk Elmas and Necmettin Akdeniz
8 Effects of retinoids at the cellular level
Jelena Popovic
9 Effects of retinoids at the systemic level
Sandra Maria Barbalho and Letícia Maria Pescinini-Salzedas
10 New aspects of isotretinoin teratogenicity
Bodo C Melnik
11 Mucocutaneous side effects
Tugba Kevser Uzuncakmak and Ayse Serap Karadag
12 Ophthalmologic side effects
Remzi Karadag and Fehim Esen
13 Musculoskeletal side effects
Filiz Cebeci Kahraman, Vefa Aslı Turgut Erdemir, and Melek Aslan Kayıran
14 Neurologic side effects
Evren Burakgazi-Dalkilic
15 Psychiatric side effects
Joshua Schimmel, Evren Burakgazi-Dalkilic, and Hatice Burakgazi-Yilmaz
16 Gastrointestinal side effects
Esra Adısen, Burcu Beksaç, and Mehmet Ali Gürer
17 Endocrine and metabolic side effects
Ayse Serap Karadag, Emin Özlü, and Bodo C Melnik
18 Other systemic side effects: Cardiovascular, pulmonary, otolaryngorhinologic, genito-urinary, renal, and immunologic
Emin Özlü, Akif Sinan Bilgen, and Ayşe Serap Karadağ
19 Retinoids in acne
Ruta Genceviciene and Christos C. Zouboulis
20 Retinoids in hydradenitis supurativa/acne inversa
Uwe Wollina, Piotr Brzezinski, and André Koch
21 Retinoids in rosacea
Marius Rademaker and Harriet Cheng
22 Retinoids in hair disorders
Brent J Doolan and Rodney Sinclair
23 Retinoids in psoriasis
Uwe Wollina, Piotr Brzezinski, and André Koch
24 Retinoids in keratinization disorders
Ümit Türsen and Belma Türsen
25 Retinoids in antiaging therapy
Zehra Aşıran Serdar and Ezgi Aktaş Karabay
26 Retinoids in other skin diseases
Uwe Wollina, Piotr Brzezinski, and André Koch
27 Retinoids in lymphoma
Robert Duffy and Joya Sahu
28 Retinoids in cutaneous chemoprophylaxis
Robert Duffy and Joya Sahu
29 Guide to good clinical practice for vulnerable populations (infancy, childhood, fertile period, elderly)
Elif Yıldırım and Berna Aksoy
30 Retinoids and concomitant surgery
H Mete Aksoy
31 Retinoids and concomitant aesthetic procedures
Zekayi Kutlubay, Ayşegül Sevim Keçici, and Yalçın Tüzün
32 Laboratory and clinical follow-up
N Burcu Öztürk and Berna Aksoy
33 Teratogenicity and registry programs
Reese L. Imhof and Megha M Tollefson
34 Management of side effects
Aslı Tatlıparmak and Berna Aksoy
35 Future and novel unexplored indications of retinoids
Kabir Sardana and Ananta Khurana
Index
Biography
Ayse Serap Karadag, MD
Department of Dermatology, Istanbul Medeniyet University, Faculty of Medicine, Göztepe Training and Research Hospital, Istanbul, Turkey
Berna Aksoy, MD
Department of Dermatology, Bahçeşehir University, Faculty of Medicine, Istanbul, Turkey
Lawrence Charles Parish, MD, MD (Hon)
Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University and Jefferson Center for International Dermatology, Philadelphia, Pennsylvania, USA
