Retinoids in Dermatology  book cover
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1st Edition

Retinoids in Dermatology




ISBN 9781138314771
Published November 14, 2019 by CRC Press
244 Pages 55 Color & 1 B/W Illustrations

 
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Book Description

Retinoids are valuable drugs in the dermatologic armamentarium, being employed in daily clinical practice. The text provides an in-depth update on the latest thinking on pharmacology, clinical use, side effects, and follow-up of retinoid therapy in dermatology; it also addresses topics related to retinoid use in special circumstances, such as vulnerable populations, concomitant surgery, and aesthetic procedures.

CONTENTS: The background of retinoids * Mechanism of action of vitamin A * Mechanism of action of topical retinoids * Mechanism of action of isotretinoin * Mechanism of action of acitretin * Mechanism of action of bexarotene * Mechanism of action of alitretinoin * Effects of retinoids at the cellular level (differentiation, apoptosis, autophagy, cell cycle regulation, and senescence) * Effects of retinoids at the systemic level * New aspects of isotretinoin teratogenicity * Mucocutaneous side effects * Ophthalmologic side effects * Musculoskeletal side effects * Neurologic side effects * Psychiatric side effects * Gastrointestinal side effects * Endocrine and metabolic side effecs * Other systemic side effects: Cardiovascular, pulmonary, otolaryngorhinologic, genitourinary, renal, and immunologic * Retinoids in acne * Retinoids in hidradenitis suppurativa/acne inversa * Retinoids in rosacea * Retinoids in hair disorders * Retinoids in psoriasis * Retinoids in keratinization disorders * Retinoids in antiaging therapy * Retinoids in other skin diseases * Retinoids in lymphoma * Retinoids in cutaneous chemoprophylaxis * Guide to good clinical practice for vulnerable populations (infancy, childhood, fertile period, elderly) * Retinoids and concomitant surgery * Retinoids and concomitant aesthetic procedures * Laboratory and clinical follow-up * Teratogenicity and registry programs * Management of vitamin A and retinoid side effects * Future and novel unexplored indications of retinoids

Published in association with the Journal of Dermatological Treatment.

Table of Contents

1 Introduction and historical background
Ayse Serap Karadag, Berna Aksoy, and Lawrence C Parish

2 Mechanism of action of Vitamin A
Sandra Maria Barbalho

3 Mechanism of action of topical retinoids
Sümeyre Seda Ertekin and Mehmet Salih Gurel

4 Mechanism of action of isotretinoin
Bodo Melnik

5 Mechanism of action of acitretin
Kaitlyn Lam and Ronald Vender

6 Mechanism of action of bexarotene
Catherine M Ludwig, Claire Wilson, Brandon Roman, and Maria M Tsoukas

7 Mechanism of action of alitretinoin
Ömer Faruk Elmas and Necmettin Akdeniz

8 Effects of retinoids at the cellular level
Jelena Popovic

9 Effects of retinoids at the systemic level
Sandra Maria Barbalho and Letícia Maria Pescinini-Salzedas

10 New aspects of isotretinoin teratogenicity
Bodo C Melnik

11 Mucocutaneous side effects
Tugba Kevser Uzuncakmak and Ayse Serap Karadag

12 Ophthalmologic side effects
Remzi Karadag and Fehim Esen

13 Musculoskeletal side effects
Filiz Cebeci Kahraman, Vefa Aslı Turgut Erdemir, and Melek Aslan Kayıran

14 Neurologic side effects
Evren Burakgazi-Dalkilic

15 Psychiatric side effects
Joshua Schimmel, Evren Burakgazi-Dalkilic, and Hatice Burakgazi-Yilmaz

16 Gastrointestinal side effects
Esra Adısen, Burcu Beksaç, and Mehmet Ali Gürer

17 Endocrine and metabolic side effects
Ayse Serap Karadag, Emin Özlü, and Bodo C Melnik

18 Other systemic side effects: Cardiovascular, pulmonary, otolaryngorhinologic, genito-urinary, renal, and immunologic
Emin Özlü, Akif Sinan Bilgen, and Ayşe Serap Karadağ

19 Retinoids in acne
Ruta Genceviciene and Christos C. Zouboulis

20 Retinoids in hydradenitis supurativa/acne inversa
Uwe Wollina, Piotr Brzezinski, and André Koch

21 Retinoids in rosacea
Marius Rademaker and Harriet Cheng

22 Retinoids in hair disorders
Brent J Doolan and Rodney Sinclair

23 Retinoids in psoriasis
Uwe Wollina, Piotr Brzezinski, and André Koch

24 Retinoids in keratinization disorders
Ümit Türsen and Belma Türsen

25 Retinoids in antiaging therapy
Zehra Aşıran Serdar and Ezgi Aktaş Karabay

26 Retinoids in other skin diseases
Uwe Wollina, Piotr Brzezinski, and André Koch

27 Retinoids in lymphoma
Robert Duffy and Joya Sahu

28 Retinoids in cutaneous chemoprophylaxis
Robert Duffy and Joya Sahu

29 Guide to good clinical practice for vulnerable populations (infancy, childhood, fertile period, elderly)
Elif Yıldırım and Berna Aksoy

30 Retinoids and concomitant surgery
H Mete Aksoy

31 Retinoids and concomitant aesthetic procedures
Zekayi Kutlubay, Ayşegül Sevim Keçici, and Yalçın Tüzün

32 Laboratory and clinical follow-up
N Burcu Öztürk and Berna Aksoy

33 Teratogenicity and registry programs
Reese L. Imhof and Megha M Tollefson

34 Management of side effects
Aslı Tatlıparmak and Berna Aksoy

35 Future and novel unexplored indications of retinoids
Kabir Sardana and Ananta Khurana

Index

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Editor(s)

Biography

Ayse Serap Karadag, MD

Department of Dermatology, Istanbul Medeniyet University, Faculty of Medicine, Göztepe Training and Research Hospital, Istanbul, Turkey

Berna Aksoy, MD

Department of Dermatology, Bahçeşehir University, Faculty of Medicine, Istanbul, Turkey

Lawrence Charles Parish, MD, MD (Hon)

Department of Dermatology and Cutaneous Biology, Sidney Kimmel Medical College at Thomas Jefferson University and Jefferson Center for International Dermatology, Philadelphia, Pennsylvania, USA