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This critical, state-of-the-art review brings together the scattered and often controversial information on multidrug resistance reversal. Leading scientists in the field cover P-glycoprotein, the genetics of resistance, and its reversal by drugs. Resistance modifiers and modulators are tabulated and critically evaluated. Reversal of Multidrug Resistance in Cancer is important reading for oncologists, cancer chemotherapists, and other cancer researchers.
Preface (J.A. Kellen). The Phenomenon of Multidrug Resistance (J.A. Kellen). Collateral Sensitization in Multidrug Resistance (J.L. Biedler and B.A. Spengler). Cytogenetics of Multidrug Resistance (R. Ganapathi, D. Grabowski, and G. Hoeltge). Mathematical Models of Multidrug Resistance (J. Goldie, A.J. Coldman, and A. Lai). Multidrug Resistance in Human Malignancies (J.A. Kellen). Reversal of Multidrug Resistance (D. Fan, P.J. Beltran, and C.A. O'Brian). Outlook (J.A. Kellen and D. Fan). Conclusion (J.A. Kellen). Index.
