This work concentrates on cellular and molecular toxicity of selected well-known drugs or chemicals on the cardiovascular system. The primary objective is to provide a better understanding of the mechanisms by which xenobiotics are toxic to mammalian tissues and cells. The use of in vitro cellular and tissue systems provides attractive experimental models to assess toxic manifestations of xenobiotics. This work addresses the most recent findings on the cellular and molecular mechanisms of toxicity of several important cardiotoxic agents: doxorubicin, ethanol, cocaine, and the catecholamines. It presents an overview of vascular toxins and their biochemical effects. Included is a summary of in vitro cardiovascular techniques for assessing toxicity of xenobiotics. This publication is important for those in toxicology, tissue culture, pharmacology, in vitro toxicology, developmental biology and related areas.
Table of Contents
The Vascular Toxicity of Xenobiotics
The Molecular and Cellular Toxicology of Ethanol on the Heart
P.I. Polimeni and P. Posner
Mechanisms of Anthracycline Cardiotoxicity: Are Metabolites Involved
R.D. Olson and P.S. Mushlin
Cardiotoxicity of Catecholamines
The Toxic Effects of Cocaine on the Heart
Cellular and Molecular Basis of Xenobiotic-Induced Cardiovascular Toxicity: Application of Cell Culture Systems
Dr Daniel Acosta, PhD., is Deputy Director for Research at US Food and Drug Administration, National Center for Toxicological Research.