1st Edition

Revival: Delivery Strategies for Antisense Oligonucleotide Therapeutics (1995)

Edited By

Saghir Akhtar

ISBN 9781138558571
Published January 25, 2019 by CRC Press
318 Pages

USD $69.95

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Book Description

With contributions from leading experts, this book is the first to focus solely on addressing the problems and reviewing the strategies currently being used to improve the delivery of antisense nucleic acids. Important delivery issues, such as improving biological stability, improving cell-specific targeting and cellular uptake, manipulating subcellular distribution and producing liposomal delivery systems for antisense agents are comprehensively covered in this volume. This book links review-type articles with contributions that contain exciting never-before-published data on the cellular delivery of oligonucleotides. It stimulates reading for both established researchers and newcomers to the antisense field.

Table of Contents

Overview of Antisense Oligonucleotide Therapeutics and Delivery
Disrupting the Flow of Genetic Information with Antisense Oligodeoxynucleotides: Research and Therapeutic Applications, D. Kregenow, M.Z. Ratajczak, and A. Gewirtz
Cellular Delivery of Ribozymes, D.A. Elkins and J.J. Rossi
Improved Structural Design and Cellular Uptake of GT-Rich Triplex-Forming Oligonucleotides, N. Choudhary, J.S. Bishop, K. Jayaraman, and J.K. Guy-Caffey
Pharmacokinetic and Distribution Studies
Pharmacokinetics and Delivery of Oligonucleotides to the Brain, L. Neckers, D.A. Geselowitz, and C. Chavany
In Vivo Pharmacokinetics of Oligonucleotides Following Administration by Different Routes, V.V. Vlassov, L.A. Yakubov, V. Karamyshev, L. Pautova, E. Rykova, and M. Nechaeva
Improving Biological Stability of Oligonucleotides
Nuclease-Resistant Nucleic Acid Therapeutics, E. Wickstrom
Self-Stabilized Oligonucleotides as Novel Antisense Agents, S. Agrawal, J. Temsamani, and J. Tang
Circular Oligonucleotides as Potential Modulators of Gene Expression, E.T. Kool
Peptide Nucleic Acids as Antisense Therapeutic Agents, J.C. Hanvey and L.E. Babiss
Stabilized RNA Analogues for Antisense and Ribozyme Applications, H. Arup, O. Heindenreich, F. Eckstein
Improving Membrane Transport and Targeted Delivery of Antisense Oligonucleotides
Uptake and Localization of Phosphodeister and Chimeric Oligodeoxynucleotides in Normal and Leukaemic Primary Cells, A. Kreig
Oligonucleotide Transport across Membranes and into Cells: Effects of Chemical Modifications, J. Hughes, A. Avroutskaya, H.M. Sasmoor, C.J. Guinosso, P.D. Cook, and R.L. Juliano
Liposomes as a Delivery System for Antisense and Ribozyme Compounds, A. Thierry and G.B. Takle
Intracellular Delivery of Oligonucleotides with Cationic Liposomes, C.F. Bennett
The Delivery of Oligonucleotides Using pH-Sensitive Liposomes, C. Ropert, P. Couvreur, and C. Malvy
Enhancing Endsosomal Exit of Nucleic Acids Using pH-Sensitive Viral Fusion Peptides, B. Oberhauser, C. Plank , and E. Wagner
Targeted Delivery of Anti-Hepatitis B Antisense Oligonucleotides, E.P. Carmichael, H.C. Chiou, M.A. Findeis, G.L. Spitalny, and J.R. Merwin
Design, Synthesis, and Cellular Delivery of Antibody Antisense Oligonucleotide Conjugates for Cancer Therapy, C.S.R. Gooden and A.A. Epenetos

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Saghir Akhtar is professor in the Department of Pharmacology and Toxicology, Faculty of Medicine, Kuwait University.