The purpose of this book is to provide comprehensive coverage and an update of the major roles of eicosanoids in reproduction. It presents considerable evidence of the importance of lipoxygenase metabolites of arachidonic acid metabolism in reproductive processes. This interesting volume embraces a multidisciplinary approach to research in reproduction (biochemistry, endocrinology, physiology, pharmacology, etc.) at all levels, from whole animal studies through organ, cellular, and molecular approaches. This one-of-a-kind work provides several clinically relevant chapters and places emphasis on the relevance to human reproduction, when applicable. This text is an excellent update for researchers and clinicians on the current state of knowledge of the role of eicosanoids in mechanisms critical for successful reproductive function. This informative, easy-to-read resource is also useful to all those with a more specific interest in obstetrics, gynecology, clinical endocrinology, and the study of fertility.
Table of Contents
1. Pathways of Arachidonic Acid Metabolism 2. Regulation of the Arachidonic Acid Cascade and PAF Metabolism in Reproductive Tissues 3. Eicosanoid Binding Sites in Ovarian and Uterine Tissues 4. Prostaglandins and Semen 5. Placental PGE2 and the Initiation of Parturition in the Sheep 6. The Role of Eicosanoids in Menstruation and Disorders of Menstruation 7. Eicosanoids and the Uterine Cervix 8. Eicosanoids and Blastocyst Implantation 9. Eicosanoids and the Regulation of Uteroplacental Hemodynamics 10. Placental Biosynthesis, Metabolism and Transport of Eicosanoids 11. Eicosanoids in Human Pregnancy and Parturition 12. Clinical Use of Eicosanoids for Cervical Ripening Before Induction of Labor 13. Eicosanoids and Hypertension in Pregnancy 14. Eicosanoids and the Ductus Arteriosus 15. The Role of Eicosanoids in the Fetal and Perinatal Circulations. Index.
Mitchell; Murray D. Utah School of Medicine, Salt Lake City,