This book provides an up-to-date summary of the large body of data regarding gastrointestinal hormones and growth factors involved in the development and maintenance of the architecture and physiological functions of the different organs of the digestive tract. The regulation of growth and differentiation in the stomach, small intestine, colon, and pancreas is reviewed by experts in developmental and adult physiology, as well as in pathophysiology of diseases involving each organ. The book provides essential reference material for gastroenterologists, medical and university libraries, and investigators and graduate students of gastrointestinal physiology.
Section 1: General mechanisms of cell proliferation and differentiation 1. Hormonal regulation of cell proliferation and differentiation: cellular mechanisms 2. Polyamines and cell and tissue growth 3. Receptors of the gastrointestinal hormones and their development. Section 2: Exocrine pancreas 1. Fetal and neonatal development of the exocrine pancreas 2. Pancreatic adaptation to diet 3. Regulation of specific enzyme synthesis 4. Pancreatic regeneration. Section 3: Stomach 1. Growth and maturation of the gastric mucosa 2. Neurohormonal regulation of gastric mucosal growth 3. Regeneration following gastric injury. Section 4: Intestine 1. Fetal and postnatal development of the small and large intestine: patterns and regulation 2. Regulation of intestinal mucosal growth. Section 5: Growth factors 1. Inhibitory regulation of gastrointestinal organ growth 2. Hormonal effects on gastrointestinal cancer growth.