Revival: Pharmacological Regulation of Gene Expression in the CNS Towards an Understanding of Basal Ganglial Functions (1996): 1st Edition (Paperback) book cover

Revival: Pharmacological Regulation of Gene Expression in the CNS Towards an Understanding of Basal Ganglial Functions (1996)

1st Edition

By Kalpana Merchant

CRC Press

224 pages

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This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines.

Table of Contents

Dopamine-Mediated Gene Expression in the Neostriatum

D1 and D2 Dopamine Receptor Mediated Gene Regulation in the Striatum, C.R. Gerfen, K.A. Keefe, and H. Steiner

Acute and Long-Term Alteration in Immediate-Early Gene Expression by Antipsychotic Drugs: Downstream Genomic Targets, Behavioral Correlates, and Role of D2, D3, and D4 Receptors, K.M. Merchant

Dopamine Receptor Function: An Analysis Utilizing Antisense Knockout In Vivo, B.-C. Sun, M. Zang, A.-M. Ouagazzal, L.P. Martin, J.M. Tepper, and I. Creese

Neurotransmitter Interactions Regulating Striatal Gene Expression

Glutamatergic and Cholinergic Regulation of Immediate-Early Gene and Neuropeptide Expression in the Striatum, J.Q. Wang and J.F. McGinty

Molecular Mechanisms of Striatal Gene Regulation: A Critical Role for Glutamate in Dopamine-Mediated Gene Induction, S.E. Hyman, R.L. Cole, M. Schwarzchild, D. Cole, B. Hope, and C. Konradi

Persistent Alterations in Gene Expression Involved in Behavioral Adaptations

Striatal Gene Expression Involved in Adaptive Responses to Levodopa in Parkinsonian Models: Relevance to Long-Term Clinical Effects of Levodopa Therapy, G.S. Robertson

Plasticity of GAD Expression in Animal Models of Movement Disorders, M.-F. Chesselet and J.M. Delfs

Pharmacological and Molecular Regulation of the Expression of Dopamine Receptors, B. Weiss, L.-W. Zhou, and G. Davidkova


About the Authors/Editor

Kalpana Mechant is President and CSO at TransThera Consulting Co., Adjunct Professor of Neurology at Northwestern University Feinberg School of Medicine, Adjunct Professor of Biology at Purdue University.

About the Series

CRC Press Revivals

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Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / General
MEDICAL / Pharmacology
SCIENCE / Life Sciences / Genetics & Genomics
SCIENCE / Life Sciences / Neuroscience