This book focuses on dopamine-mediated regulation of gene expression within the striatum and associated regions of the central nervous system. It is an excellent review of experimental data on interactions between neuronal systems at systemic, cellular, and molecular levels. Each of the chapters, written by the world's leading scientists, provides an understanding of anatomy, neurochemistry, and cellular and molecular effects. Such an understanding sheds light on the pathophysiology of central disorders involving the basal ganglia and leads to new approaches for the treatment of diseases such as Parkinson's disease and schizophrenia, and also addictions to psychostimulants such as cocaine and amphetamines.
Table of Contents
Dopamine-Mediated Gene Expression in the Neostriatum
D1 and D2 Dopamine Receptor Mediated Gene Regulation in the Striatum, C.R. Gerfen, K.A. Keefe, and H. Steiner
Acute and Long-Term Alteration in Immediate-Early Gene Expression by Antipsychotic Drugs: Downstream Genomic Targets, Behavioral Correlates, and Role of D2, D3, and D4 Receptors, K.M. Merchant
Dopamine Receptor Function: An Analysis Utilizing Antisense Knockout In Vivo, B.-C. Sun, M. Zang, A.-M. Ouagazzal, L.P. Martin, J.M. Tepper, and I. Creese
Neurotransmitter Interactions Regulating Striatal Gene Expression
Glutamatergic and Cholinergic Regulation of Immediate-Early Gene and Neuropeptide Expression in the Striatum, J.Q. Wang and J.F. McGinty
Molecular Mechanisms of Striatal Gene Regulation: A Critical Role for Glutamate in Dopamine-Mediated Gene Induction, S.E. Hyman, R.L. Cole, M. Schwarzchild, D. Cole, B. Hope, and C. Konradi
Persistent Alterations in Gene Expression Involved in Behavioral Adaptations
Striatal Gene Expression Involved in Adaptive Responses to Levodopa in Parkinsonian Models: Relevance to Long-Term Clinical Effects of Levodopa Therapy, G.S. Robertson
Plasticity of GAD Expression in Animal Models of Movement Disorders, M.-F. Chesselet and J.M. Delfs
Pharmacological and Molecular Regulation of the Expression of Dopamine Receptors, B. Weiss, L.-W. Zhou, and G. Davidkova
Kalpana Mechant is President and CSO at TransThera Consulting Co., Adjunct Professor of Neurology at Northwestern University Feinberg School of Medicine, Adjunct Professor of Biology at Purdue University.