This series of books on Radiotracers in Biology and Medicine is on the one hand an unbelievably expansive enterprise and on the other hand, a most noble one as well. Tools to probe biology have developed at an accelerating rate. Hevesy pioneered the application of radioisotopes to the study of chemical processes, and since that time radioisotopic methodology has probably contributed as much as any other methodology to the analysis of the fine structure of biologic systems. Radioisotopic methodologies represent powerful tools for the determination of virtually any process of biologic interest. It should not be surprising, therefore, that any effort to encompass all aspects of radiotracer methodology is both desirable in the extreme and doomed to at least some degree of inherent failure. The current series is assuredly a success relative to the breadth of topics which range from in depth treatise of fundamental science or abstract concepts to detailed and specific applications, such as those medicine or even to the extreme of the methodology for sacrifice of anaimals as part of a radiotracer distribution study.
Table of Contents
SECTION III: PHARMACOKINETIC MODELLING OF RECEPTOR-BINDING RADIOTRACERS
Application of Modelling Principles to Receptor-Binding radiotracers
Pharmomacokinetic Aspects of the In Vivo, Noninvasive Study of Neuroreceptors in Man
A Complimentary Radiopharmaceutical and Mathematical Model for Quantitating Hepatic-Binding Protein Receptors
Separating Changes in Flow from Changes in Receptor Binding by Pharmacokinetic Modelling
SECTION IV: INSTRUMENTATION FOR RECEPTOR-BINDING RADIOTRACERS
Simulated Uptake Ratio Requirements for Spherical Lesions Imaged with a Conventional Scintillation Camera
Potential of Longitudinal Tomography for Imaging Receptor-Binding Radiotracers
Emission Tomography-Detection of Single Photons with Multidetector Devices and Rotating Gamma Cameras
Instrumentation for Quantitative Tomographic Determination of Concentration of Positron-Emitting, Receptor-Binding Radiotracers
SECTION V: CLINICAL RELEVANCE OF RECEPTOR-BINDING RADIOTRACERS
Introduction: The Role of Receptors in Disease
Williams C. Eckelman, Ph.D. is Professor of Radiology and Chief of Radiopharmaceutical Chemistry at George Washington University Medical Center in Washington D.C.
Dr. Eckelman receieved his B.S. in chemistry from St. Louis University and a M.A. and Ph.D in chemistry from Washington University in St. Louis. He is a member of the Society of Nuclear Medicine, the American Chemical Society and AAAS. He has published over 100 scientific papers and several book chapters.