Regulatory Mechanisms in Gastrointestinal Function includes a collection of contemporary topics in gastrointestinal research. The control of gastroduodenal electrolyte transport and the influence of drugs on bicarbonate secretion are reviewed in detail. The importance of the interactions between calcium and cyclic-AMP in intestinal secretion is emphasized in a comprehensive chapter that systematically addresses each link in the mechanisms that regulate chloride secretion. Other important topics included in the book are neural reflex modulation of intestinal epithelial transport, the influence of the microcirculation on intestinal secretion, and nitric oxide as a mediator of physiologic and pathophysiologic secretion. The expertise of the authors has resulted in a breadth of important contemporary topics covered in depth.
Table of Contents
Gastroduodenal Bicarbonate Secretion: Pharmacologic Modulation and Contribution to Mucosal Protection, K. Takeuchi and S. Okabe, Kyoto Pharmaceutical University
Intestinal Chloride Secretion: cAMP/Ca2+ Interactions, V. Calderaro and F. Rossi, Second University of Naples, Italy
Neural Reflex Modulation of Intestinal Epithelial Transport, O. Lundgren and M. Jodal, University of Goteborg, Sweden
Importance of the Microcirculation to Intestinal Secretion, D. Mailman, University of Houston
Nitric Oxide as a Mediator of Intestinal Mucosal Function, M.J.S. Miller , Lousiana State University Medical Center and T.S. Gaginella, University of Wisconsin
Serotonin Mediation of Intestinal Peristalsis, T.K. Smith and R.W. McCallum, University of Virginia
Dopaminergic Mechanisms in GI Motality, J. Wiley , Toku Takahashi , and C. Owyang, University of Michigan Medical Center
Pharmacology of Endothelins in the Gastrointestinal Tract, G.A. Rae, University of Santa Catarina, Brazil
Hindbrain Neuroactive Substances Controlling Gastrointestinal Function, Z.K. Krowicki and P.J. Hornby, Louisiana State University
Timothy S. Gaginella, Ph.D., is Adjunct Professor of Pharmacology in the School of Pharmacy, the University of Wisconsin.