The focus of this book is on subjects related to drug delivery to the lung. The text spans topics from aerosol deposition through pharmaceutical chemistry and formulation to the final clinical evaluation of pharmaceutical products. Utilizing a multi-disciplinary approach, the chapters consider toxicology from the point of view of drugs and pharmaceutical excipients used in aerosols.
Table of Contents
Pathophysiological and Disease Constraints on Aerosol Delivery
Toxicological Responses to Inhaled Aerosols and Their Ingredients
Drug Application to the Respiratory Tract: Metabolic and Pharmacokinetic Considerations
Pro-Drugs for Pulmonary Drug Targeting
Absorption, Clearance, and Dissolution in the Lung
Aerosol Formulation, Generation, and Delivery Using Nonmetered Systems
Aerosol Formulation, Generation, and Delivery Using Metered Systems
Clinical Testing of Aerosol Drugs
The Effects of Water Inhalation Suspendion Aerosol Formulations
Peter R. Byron, Ph.D. is Associate Professor of Physical Pharmacy, Department of Pharmacy and Pharmaceutics, Medical College of Virginia/Virginia Commonwealth University School of Pharmacy, Richmond, VA.