This book would like to present the latest findings on different aspects of tumor matrix formation in connection with the tumor progression and metastasis and on alterations in the cellular components of tumor stroma during tumor demarcation and invasion. The contributors shed new light on the relationship between tumor cells and their extracellular microenvironment as well as on the mechanisms of fibrin/fibronectin network formation characteristics in tumors. These reviews provide insights into the formation and organization of tumor matrix during growth and metastasis and also offerthe possibility of learning to interfere with the metastatic cascade by manipulation of adhesion, coagulation and/or fibrinolytic events.
Table of Contents
Immunohistochemical Characterizaion of Extracellular Matrix in Tumor Tissue
Differential Expression of Proteogycans on the Surface of Malignant Cells and in the Tumor Stroma
Overproduction of Hyaluronan in the Tumor Stroma
Differential Expression of Fibronectin and its Degradation Products in Malignant Tumors
Role of Tenascin in Cancer Development
Composition of the Extracellular Matrix in Human Gliomas
Integrin Expression in Tumor Progression -- Role of Signaling Mechanisms
Tumor-Associated Macrophages and Their Modulatory Role in Tumor Progression
The Coagulation-Cancer Interaction in Situ
Intratumoral Fibrin Formation
Modulation of Tumor Matrix by Components of the Plasminogen-Plasmin System
Roza Adany, M.D., Ph.D., D.Sc. is Professor of Hygiene and Epidemiology at University School of Medicine Debrecen, Hungary.