First published in 1994, Role of Procoagulant Activity in Health and Disease discusses different aspects of the pathobiology and consequences of the induction of cellular procoagulants. The first part of the book addresses the molecular and cellular biology of procoagulant activity induction (PCA). This includes the recent data on cellular pathways of induction of PCA and the molecular nature of the different procoagulants identified to date. The book addresses interactions between macrophages and endothelial cells, focusing on those aspects most relevant to induction of procoagulant activities, including the role of adhesion molecules. The second portion of the book describes the relevance of PCA to a number of human and experimental diseases, including infectious diseases, gastrointestinal diseases, liver disease, renal disease, neoplastic diseases, allograft rejection, and pulmonary disease. This book will not only be of value to the basic scientist, but also to pathologists and clinicians, and to others wishing to understand the role of immunologically mediated induction of cellular coagulants and their relevance to disease.
Table of Contents
Biology: Pathways for Induction and the Nature of Macrophage Procoagulant Activity (R.J. Fingerote and G.A. Levy). The Role of Cytokines in Induction of Macrophage Procoagulant Activity (C.L. Geczy). Monocyte/Macrophage-Endothelial Cell Interactions (E.H. Cole and P.A. Marsden). Role of Procoagulant Activity in Disease: The Role of Macrophage Procoagulants in Infection (G.F. Brisseau, P.Y.C. Cheung, and O.D. Rotstein). Procoagulant Activity in Gastroenterology (A.J. Wakefield, M. Hudson, and L. More). The Role of Procoagulant Activity in Fulminant Viral Hepatitis (S.W. Chung, C.-Y. Li, J. Leibowitz, and G.A. Levy). Procoagulant Activity in Diseases of the Kidney (S. Holdsworth and P. Tipping). Role of Procoagulant Activity in Neoplastic Disease (R.L. Edwards and F.R. Rickles). Role of Procoagulant Activity PCA in Allograft Rejection (P. Kim, I. Koh, and Z. Cohen). Procoagulant Activity and Lung Disease (H.A. Chapman, J.S. Munger, and D.A. Waltz). Index.
Gary A. Levy, Edward H. Cole