Roman Edessa offers a comprehensive and erudite analysis of the ancient city of Edessa (modern day Urfa, Turkey), which constituted a remarkable amalgam of the East and the West. Among the areas explored are:
- the cultural life and antecedents of Edessa
- Edessene religion
- the extent of the Hellenization at Edessa before the advent of Christianity
- the myth of an exchange of letters between a King Abgar and Jesus.