1st Edition

Severe Pulmonary Emphysema: A Comprehensive Guide to Precision Interventional Procedures

    192 Pages 29 Color & 20 B/W Illustrations
    by CRC Press

    192 Pages 29 Color & 20 B/W Illustrations
    by CRC Press

    “Chronic Obstructive Pulmonary Disease is, in 2024, one of the three main causes of death in the world, affecting around 12% of the world population and its incidence is estimated to increase in the coming decades due to continuous exposure to risk factors and to aging. population.

    Pulmonary emphysema is one of its most serious phenotypes, with chronic and inexorable progression and, in the most severe stages, it is highly disabling and lethal.

    This book reviews knowledge about the pathophysiology of severe pulmonary emphysema and current innovative interventional and minimally invasive therapeutic concepts for the management of these advanced stages of emphysema, based on the best scientific evidence.

    This guide provides, to multidisciplinary pulmonary boards of experts in advanced lung diseases, current criteria for the choice of precision therapeutic options, beyond to maintaining optimized medical treatment to control lung hyperinflation and alleviate patients' symptoms.

    This book is a valuable resource for clinicians dealing with critically ill patients with COPD.”

    Chapter 1. Pathophysiology of Emphysema

    José R. Jardim


    Chapter 2. Pulmonary Functional Evaluation for Safe Performance of BLVR

    Jin Sun Kim and Gerard J. Criner


    Chapter 3 The concept of lung volume reduction and the best evidence

    Nathaniel Marchetti and Gerard J. Criner


    Chapter 4. Surgical Concept and Technique of Lung Volume Reduction Surgery

    Laurens J. Ceulemans, Christelle M. Vandervelde, Claudio Caviezel and Walter Weder


    Chapter 5. Image Analysis to Identify Target Areas for Lung Volume Reduction

    Maruti Kumaran, Yogesh Gupta and Chandra Dass


    Chapter 6. Nuclear Medicine Techniques in Pre-evaluation of Single Pulmonary Nodule Resection, Lung Volume Reduction Surgery and Pre and Post Bronchoscopic Lung Volume Reduction

    Sean I. Bolet, Gerard Criner and Simin Dadparvar


    Chapter 7. The Precision Treatment for Severe Lung Emphysema and the Impact of the Multidisciplinary Lung Board

    Luis C. Losso, Marina Dornfeld C. Castro, Mario C. Ghefter and Marcel M. Sandrini


    Chapter 8. The Current Optimized Medical Treatment and the Impact on Dynamic Hyperinflation

    José R. Jardim


    Chapter 9. Lung Volume Reduction Surgery: Technique, Tips and Challenges Andrew Akcelik and Charles T. Bakhos


    Chapter 10. Extending Candidacy for Lung Volume Reduction Surgery

    Claudio Caviezel, Laurens Ceulemans and Walter Weder


    Chapter 11. The Interface Lung Emphysema and Lung Cancer

    Mario C. Ghefter, Ricardo S. Santos and Luis C. Losso


    Chapter 12. Bronchoscopic Lung Volume Reduction Innovations

    Justin L. Garner and Pallav L. Shah


    Chapter 13. Peri-Interventional Clinical Management of Endoscopic Emphysema Treatment

    Johannes Wienker and Kaid Darwiche


    Chapter 14. Bronchoscopic Lung Volume Reduction with One-Way Valves: Prevention and Management of Complications

    T. David Koster, Hugo G. Oliveira and Dirk-Jan Slebos


    Chapter 15. Pulmonary Rehabilitation for COPD Patients

    José R. Jardim


    Chapter 16. Results and Long-Term Follow Up of Interventional Treatments for Lung Emphysema: Quality of Life Considerations

    Alexey Abramov, Mark E. Ginsburg and Bryan P. Stanifer


    Chapter 17. The Future of Treating Hyperinflation in Emphysema

    Justin L Garner and Pallav L Shah



    Luis Carlos Losso, MD, PhD

    Director, Center for Thoracic Medicine and Minimally Invasive Thoracic Surgery, Hospital Edmundo Vasconcelos, São Paulo, Brazil;

    Director, Research Center for Thoracic Medicine, São Paulo, Brazil;

    COPD Foundation, Brazilian Captain, USA;

    Latin American Thoracic Advisory Board for Minimally Invasive Thoracic Surgery, Professional Education, Johnson & Johnson Institute.

    Philosophical Degree in Medicine, Postgraduate Program in Operative Technique and Experimental Surgery at the Escola Paulista de Medicine at the Federal University of São Paulo; Brazil

    Certification of Specialist in Thoracic Surgery, Brazilian Society of Thoracic Surgery; 

    Certification of Specialist in Pulmonology, Brazilian Society of Pulmonology;

    1972 Graduation in Medicine, Faculty of Medicine of Marília;

    As an author, he published scientific papers in national and international medical journals; he is editor of Thoracic Surgery books; wrote chapters on Thoracic Surgery books; speaker of international and national lectures on Thoracic Surgery; Former President of the South American Chapter of the International Minimally Invasive Thoracic Surgery Group (USA); Founder of the Brazilian Society of Thoracic Surgery; Founder of the Brazilian Society of Pulmonology; Member of the Ibero-American Association of Thoracic Surgery; Member of the Latin American Thoracic Association.



    Prof. Pallav Shah, MD, MBBS, FERS, FRCP

    Professor Pallav Shah is currently Professor of Respiratory Medicine at Imperial College, London, He is a Senior Consultant Physician the Royal Brompton Hospital, and Chelsea & Westminster Hospital. He qualified in Medicine at Guy’s Hospital Medical School, London and trained in pulmonology at the Royal Brompton Hospital.

    Professor Shah is active in both the research and the development of new treatments. He has over 250 papers and several books – including his contribution as sectional editor of the thoracic section of Grays Anatomy (39th & 40th editions) and as sectional editor for respiratory section of the Oxford textbook of Medicine (6th edition). He also the author of an Atlas of Flexible Bronchoscopy and chief editor of Essentials of Clinical Pulmonology. He has also been involved in the HERMES education program for the European Respiratory Society

    Professor Pallav Shah has pioneered bronchoscopic lung volume reduction for emphysema with devices such as the Zephyr endobronchial valves, endobronchial coils, Vapor treatment, and Intrabronchial valves. More recently he has been focused on the treatment of COPD with Vapor therapy, targeted nerve ablation and the novel Rejuvenair (cryospray) procedure for chronic bronchitis.



    Gerard J. Criner, MD

    Gerard J. Criner, M.D., is Professor and Founding Chair of the Department of Thoracic Medicine and Surgery and Temple Lung Center at the Lewis Katz School of Medicine at Temple University in Philadelphia, PA. His research interests include respiratory failure, lung volume reduction surgery, bronchoscopic lung reduction and the prevention and treatment of acute COPD exacerbations.



    Walter Weder, MD
    Professor of Surgery, Chief of the Division of Thoracic Surgery, University Hospital Zurich. Zurich, CHE.






    José R. Jardim, MD

    Graduated in Medicine in 1970 at the Escola Paulista de Medicina, Federal University of São Paulo, Brazil, where he was later awarded his PhD in Medical Sciences. He has also completed a 2-year fellowship in respiratory pathophysiology from the McGill University in Montreal, Canada.

    Senior Professor of Respiratory Diseases and the former Director of the Pulmonary Rehabilitation Centre at Escola Paulista de Medicina of Federal University of São Paulo, Brazil, for over 30 years

    Chairman of the Education Department twice and served as Chairman of the COPD Committee three times of the Brazilian Thoracic Society (SBPT). Member of the Planning Committee of the Rehabilitation Assembly of American Thoracic Society (ATS) for five years and served at the Nominating Committee of the same Assembly. Served on the Board of Directors of ATS representing the International Community. President of the Latin American Thoracic Society (ALAT) for two terms and one term for the Brazilian Association for Asthmatic Patients. Currently is on the Editorial Boards for several Brazilian and International Journals, has published a book on rehabilitation and have published over 250 peer reviewed papers and 90 chapters. His main interests are asthma, COPD and pulmonary rehabilitation.