1st Edition

Signal Transduction and Smooth Muscle

Edited By Mohamed Trebak, Scott Earley Copyright 2019
    432 Pages
    by CRC Press

    432 Pages 32 Color & 39 B/W Illustrations
    by CRC Press

    432 Pages 32 Color & 39 B/W Illustrations
    by CRC Press

    All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of luminal contents and storage by the contraction and relaxation of smooth muscle cells. Smooth muscle cells respond to numerous inputs, including pressure, shear stress, intrinsic and extrinsic innervation, hormones and other circulating molecules, as well as autocrine and paracrine factors. This book is a review of smooth muscle cell regulation in the cardiovascular, reproductive, GI, and other organ systems with emphasis on calcium and receptor signaling.



     



    Key selling features:





    • Focuses on smooth muscles of different types


    • Describes ion channel signaling mechanisms


    • Reviews calcium and receptor signaling


    • Includes novel, cutting-edge methodologies


    • Summarizes studies of mice with genetically encoding sensors in smooth muscle


    Chapter 9 of this book is freely available as a downloadable Open Access PDF under a CC-BY 4.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781498774222_oachapter9.pdf



    Series Preface



    Preface



    Editors



    Contributors





    Chapter 1 Elucidation of Vasopressin Signal Transduction Pathways in Vascular Smooth Muscle



    Kenneth L. Byron and Lyubov I. Brueggemann





    Chapter 2 Investigating Chloride Channels in Smooth Muscle



    Henry R. Askew Page and Iain A. Greenwood





    Chapter 3 Methods for the Isolation of and Study of Ca2+ Signaling in Arteriolar Smooth Muscle Cells



    William F. Jackson





    Chapter 4 Ion Channel Trafficking in Arterial Smooth Muscle Cells and Functional Significance



    M. Dennis Leo and Jonathan H. Jaggar





    Chapter 5 Total Internal Reflection Fluorescence Microscopy in Vascular Smooth Muscle



    Madeline Nieves-Cintrón, Sendoa Tajada, L. Fernando Santana, and Manuel F. Navedo





    Chapter 6 T-Type Ca2+ Channels in Vascular Smooth Muscle: Properties, Regulation, and Function



    Osama F. Harraz, Ahmed M. Hashad, and Donald G. Welsh





    Chapter 7 Calcium Sensitization in Smooth Muscle Involving Regulation of Myosin Light Chain Phosphatase Activity



    Justin A. MacDonald, Michael P. Walsh, and William C. Cole





    Chapter 8 Approaches for Investigating the Functional Significance of Transient Receptor Potential Cation Channels in Smooth Muscle Cells



    Harry A. T. Pritchard, Paulo W. Pires, and Scott Earley





    Chapter 9 Mitochondria Structure and Position in the Local Control of Calcium Signals in Smooth Muscle Cells



    John G. McCarron, Christopher Saunter, Calum Wilson, John M. Girkin, and Susan Chalmers





    Chapter 10 ORAI Channels in Vascular Smooth Muscle



    Maxime Guéguinou, Xuexin Zhang, Trayambak Pathak, Scott Emrich, Ryan Yoast, and Mohamed Trebak





    Chapter 11 G Protein-Coupled Receptors in Airway Smooth Muscle Function and Obstructive Lung Disease



    Tonio Pera and Raymond B. Penn





    Chapter 12 Brain-Derived Neurotrophic Factor in Airway Smooth Muscle: Contributions to Asthma



    Michael Thompson, Rodney Britt Jr, Anne Roesler, Katelyn Cummings, Christina M. Pabelick, and Y. S. Prakash





    Chapter 13 Antibody-Based Approaches for Protein Analysis of Smooth Muscles



    Brian A. Perrino and Yeming Xie





    Chapter 14 Role of Ion Channels in Urinary Bladder Smooth Muscle Function



    Georgi V. Petkov





    Chapter 15 Methods for Investigating the Regulation of Smooth Muscle Excitability by Interstitial Cells



    Bernard T. Drumm and Kenton M. Sanders





    Chapter 16 Electrical Pacemaking in Lymphatic Vessels



    Scott D. Zawieja, Jorge A. Castorena-Gonzalez, Kim H. T. To, Peichun Gui, Timothy Domeier, and Michael J. Davis





    Chapter 17 NADPH Oxidase, Redox Signaling, and Vascular Smooth Muscle Function



    Daniel S. de Jesus, Eugenia Cifuentes-Pagano, Sanghamitra Sahoo, and Patrick J. Pagano





    Index

    Biography



    Mohamed Trebak is Professor of Cellular and Molecular Physiology at the Penn State Hershey College of Medicine.



    Scott Earley is Associate Professor of Pharmacology at the University of Nevada Reno.