Signal Transduction in Leukocytes presents important principles and various aspects of cellular regulation in leukocytes. The book discusses receptor structure and signaling, emphasizing cytokine receptors and the T cell and B cell antigen receptors. It investigates the role of the heterotrimeric G proteins and small G proteins as transducers.
Authorities in each field cover a wide range of topics. They explore propagation of signaling cascades through second messengers and serine/threonine kinases, the initiation of signaling from the B and T cell antigen receptors by tyrosine phosphorylation and protein recruitment, and the role of signaling in cell-cell interactions and the regulation of the cell cycle. The book outlines the relationship of receptor signaling to inflammatory reactions of neutrophils, eosinophils, and macrophages.
Overview of Signal Transduction in Leukocytes. Signal Transduction from Cytokine Receptors. Structure and Function of Receptor-Associated G Proteins. Role of Small GTP-Binding Proteins in Leukocyte Signal Transduction. Emerging Paradigms of Protein Phosphorylation in Mitogenic Signal Transduction. Regulation of src Family PTKs during T Cell Activation. The B Cell Antigen Receptor and Its Role in B Lymphocyte Regulation. Signal Transduction in the Human Neutrophil. Eosinophils: Receptors and Signal Transduction. Intracellular Signaling Pathways Regulating Inflammatory Gene Expression in Mononuclear Phagocytes. Appendix.