Written for a readership with a basic understanding of molecular and cell biology, and intended for graduate students and researchers, this text provides an overview of signal transduction. Common themes and structures are emphasized, and there are extensive cross-references between chapters.
Part 1 Cell Surface Receptors. 1. Signaling through receptor tyrosine kinses. 2. Singal transduction through class I receptors. 3. Signaling though cytokine class II receptors. 4. Singaling though hematopoietic antigen receptors. 5. Signaling though protein serine/threonine kinase receptors. 6. Singaling though members of the tumor necrosis. 7. Signaling through G-protein-coupled receptors. 8. Receptor-mediated endocytosis of growth factors. Part 2 Cytoplasmic Signal Transduction. 9. SH2, SH3 and PH domains. 10. Ras signaling. 11. MAP kinases in multiple signaling transduction. 12. Function of phospholipases in signal transduction. 13. Multiple roles for phosphoinositide 3-kinases in signal transduction. 14. Calcium signaling. 15. Cyclic AMP and cyclic GMP in cell signaling. 16. The protein kinase C egen family. 17. Protein tyrosine phosphates. 18. Protein serine/threonine phosphatases. 19. G proteins in signal transduction. Part 3 Nuclear Reponses. 20. Steroid hormone and nuclear receptors. 21. Transcription factors. 22. The p53 tumor suppressor. 23. Cell cycle regulation.