Signaling Mechanisms Regulating T Cell Diversity and Function  book cover
1st Edition

Signaling Mechanisms Regulating T Cell Diversity and Function

ISBN 9781498705080
Published March 9, 2017 by CRC Press
258 Pages 3 Color & 25 B/W Illustrations

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Book Description

T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.

Table of Contents

Chapter 1 Consequences of Blocking the Choreography of Double

Negative Thymocyte Maturation

John B. Barnett

Chapter 2 In Situ Analysis of T Cell Receptor Signals during Positive


Nathalie Labrecque, Mengqi Dong, Aditi Sood,

and Heather J. Melichar

Chapter 3 Regulation of Negative Selection in the Thymus by Cytokines:

Novel Role of IL-23 to Regulate RORγt

Robert M. Lowe, Hao Li, Hui-Chen Hsu, and John D. Mountz

Chapter 4 Modulating Thymic Negative Selection with Bioengineered

Thymus Organoids

Isha Pradhan, Asako Tajima, Suzanne Bertera,

Massimo Trucco, and Yong Fan

Chapter 5 ThPOK, a Key Regulator of T Cell Development and Function

Jayati Mookerjee-Basu, Sijo V. Chemmannur, Li Qin,

and Dietmar J. Kappes

Chapter 6 TCR Signaling Circuits in αβ/γδ T Lineage Choice

Shawn P. Fahl, Dietmar J. Kappes, and David L. Wiest

Chapter 7 Phenotypic and Functional Characterization of Regulatory

T Cell Populations

Louis-Marie Charbonnier and Talal A. Chatila

Chapter 8 Natural Killer T (NKT) Cells in Mice and Men

Nicola M. Heller, Rosa Berga-Bolanos, Lynette Naler,

and Jyoti Misra Sen

Chapter 9 Transmission of T Cell Receptor-Mediated Signaling

via the GRB2 Family of Adaptor Proteins

Mahmood Y. Bilal and Jon C. D. Houtman

Chapter 10 Defining the Roles of Ca2+ Signals during T Cell Activation

Elsie Samakai, Christina Go, and Jonathan Soboloff

Chapter 11 Histone Methyltransferases and T Cell Heterogeneity

Janaki Purushe and Yi Zhang

Chapter 12 Models of Regulatory T Cell Alterations and Systemic


Jonathan J. Cho, Kyle J. Lorentsen, and Dorina Avram


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Jonathan Soboloff is a Professor in the Fels Institute for Cancer Research and Molecular Biology at Temple University in Philadelphia, Pennsylvania. He received his BS from University of Waterloo, Waterloo, Canada, in 1992, and his PhD from the University of Ottawa in 1998. He was a postdoctoral fellow in the Departments of Immunology (1998 to 2002) and Pathobiology & Laboratory Medicine (2002 to 2004) at the University of Toronto and a Research Associate in the Department of Biochemistry, University of Maryland 2004 to 2007. In 2007, he became an Assistant Professor in the Department of Biochemistry at Temple University. He was promoted to Associate Professor with tenure in 2013. In 2015, he transferred his primary affiliation to his current position at the Fels Institute. Finally, in 2017, he was promoted to the rank of Full Professor with Tenure. Dr. Soboloff’s research interests focus primarily on understanding STIM-mediated Ca2+ signaling, particularly in the context of T cell development and activation. Dr. Soboloff’s contributions include many fundamental insights into the roles of STIM and Orai in store-operated Ca2+ signaling and defining alternative roles for STIM1 particularly in the context of T cell activation. Understanding how Ca2+ signals are translated into physiological and pathophysiological responses is a special interest of the lab which has also led to contributions in the areas of melanoma and bone physiology. Dr. Soboloff has completed over 60 publications and is an editorial board member of The Journal of Cellular Physiology, Cell Calcium and Clinical Sciences.

Dietmar Kappes, Ph.D, is a professor and director of the Fox Chase Cancer Center in Philadelphia, Pennsylvania, USA.