Silica and Silica-Induced Lung Diseases: 1st Edition (Hardback) book cover

Silica and Silica-Induced Lung Diseases

1st Edition

By Vincent Castranova, William E. Walker, Val Vallyathan

CRC Press

432 pages | 34 B/W Illus.

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Hardback: 9780849347092
pub: 1995-12-20
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This book represents a comprehensive review of current concepts concerning the development, progression, and treatment of silica-induced lung diseases. The text begins with a complete review of the historical evolution of our understanding of silicosis and a discussion of the clinical and pathological features of this disease. It presents critical questions that must be resolved and then details state-of-the-art experiments that address these problems. The book presents an extensive discussion of new technologies that have increased our understanding of the relationship of surface properties of particulates to their cytotoxicity and pathogenicity. It also presents data that explain the intracellular and intercellular mechanisms involved in the pulmonary response to silica exposure.

Table of Contents

Background and Definitions

Pathogenic Considerations Regarding Disease Related to Silica Dust Exposure, J. Craighead

History of Silicosis, R.A. Harley and V. Vallyathan

Guidelines and Limits for Occupational Exposure to Crystalline Silica, F.J. Hearl

Clinical Features of Silicosis, D.E. Banks

Pathologic Responses to Inhaled Silica, F.H.Y. Green and V. Vallyathan

Current Concepts Concerning Physiochemical Properties of Silica

The Structure of Crystalline SiO2, G. Mandel and N. Mandel

The Structure of Silica Surfaces in Relation to Cytotoxicity, P.P. Bolsaitis and W.E. Wallace

Role of Surface Free Radicals in the Pathogenicity of Silicosis, V. Castranova, N.S. Dalal, and V. Vallyathan

Surface Properties of Silica in Mixed Dusts, W.E. Wallace, M.J. Keane, J.C. Harrison, J.W. Stephens, P.S. Brower, R.L. Grayson, and M.D. Attfield

Pathogenesis of Silicosis: Current Theories

Questions and Controversies About the Pathogenesis of Silicosis, A.B. Kane

Potential Intracellular Messengers Involved in Silica Stimulation of Alveolar Macrophages, A.J. Jabbour, R. Iyer, R.K. Scheule, and A. Holian

Calcium-Mediated Silica Cytotoxicity, Y. Rojanasakul, V. Castranova, D.E. Banks, and J.K.H. Ma

The Role of Interleukin-1 and Tumor Necrosis Factor a in the Lung's Response to Silica, K.E. Driscoll

Oxidant Release from Pulmonary Phagocytes, V. Castranova, J.M. Antonini, M.J. Reasor, L. Wu, and K. Van Dyke

Lavagable Biomarkers of Exposure to Fibrogenic Dusts, T.D. Sweeney and J.D. Brain

Early Role of Lipid Inflammatory Mediators in Silica Toxicity: Possible Methods to Detoxify Silica, K. Van Dyke, J. Gutierrez, C. Van Dyke, and L. Wu

Acute Silicosis and the Activation of Alveolar Type II Cells, G.E.R. Hook and C.J. Viviano

Fibrogenic Factors: Identity and Mode of Release, L. Couch and P.B. Bitterman

Immunological Aspects of Silicosis, R. Iyer and A. Holian

Surface Modification and Disease Prevention Modalities

Pulmonary Surfactant Adsorption and the Expression of Silica Toxicity, M.J. Keane and W.E. Wallace

Suppression of Silica-Induced Toxicity with Organosilane Surface Coating, V. Castranova, K. Van Dyke, L. Wu, N.S. Dalal, and V. Vallyathan

Suppression of the Cytotoxicity and Fibrogenicity of Silica with PVPNO, V. Castranova

Modulation of Quartz Toxicity by Aluminum, G.M. Brown and K. Donaldson

Bisbenzylisoquinoline Alkaloids: Animal Studies, V. Castranova, J.K.H. Ma, and J.Y.C. Ma

Bisbenzylisoquinoline Alkaloids: Experience from China, C. Zou, X. Lu, and S. Lu

Pharmaceutical Considerations in the Use of Tetrandrine to Treat Silicosis, J.K.H. Ma, D.-H. Chao, J.Y.C. Ma, A. Hubbs, and V. Castranova

Silica and Cancer - A Current Issue

Carcinogenesis by Crystalline Silica: Animal, Cellular, and Molecular Studies, U. Saffiotti, A.O. Williams, L.N. Daniel, M.E. Kaighn, Y. Mao, and X. Shi

Silica and Lung Cancer, J.C. McDonald

Potential Mechanisms of Silica-Induced Cancer, Z.-W. Gu and T.-m. Ong


Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Pulmonary & Thoracic Medicine
NATURE / Environmental Conservation & Protection
TECHNOLOGY & ENGINEERING / Industrial Health & Safety