Simulation for Designing Clinical Trials: A Pharmacokinetic-Pharmacodynamic Modeling Perspective, 1st Edition (Paperback) book cover

Simulation for Designing Clinical Trials

A Pharmacokinetic-Pharmacodynamic Modeling Perspective, 1st Edition

Edited by Hui Kimko, Stephen B. Duffull

CRC Press

424 pages

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Description

Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to clinical trial designs according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.

Table of Contents

Introduction to Simulation for Design of Clinical Trials. Models for Simulation. Computation in Simulation. Analyses of the Simulations. Perspectives on Clinical Trial Simulation. Applications. Index.

About the Editors

Hui C. Kimko, Stephen B. Duffull

Subject Categories

BISAC Subject Codes/Headings:
MED071000
MEDICAL / Pharmacology
SCI013000
SCIENCE / Chemistry / General