Simulation for Designing Clinical Trials : A Pharmacokinetic-Pharmacodynamic Modeling Perspective book cover
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Simulation for Designing Clinical Trials
A Pharmacokinetic-Pharmacodynamic Modeling Perspective





ISBN 9780367395605
Published September 19, 2019 by CRC Press
424 Pages

 
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Book Description

Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation practices. The book discusses how to clinical trial designs according to their probability for success, techniques to define distributions of virtual subjects' characteristics, methods to determine the sensitivity of the trial design, and the population relationship between dosing schedules and patient response.

Table of Contents

Introduction to Simulation for Design of Clinical Trials. Models for Simulation. Computation in Simulation. Analyses of the Simulations. Perspectives on Clinical Trial Simulation. Applications. Index.

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Editor(s)

Biography

Hui C. Kimko, Stephen B. Duffull