Single-stranded RNA phages: From molecular biology to nanotechnology, 1st Edition (Hardback) book cover

Single-stranded RNA phages

From molecular biology to nanotechnology, 1st Edition

By Paul Pumpens

CRC Press

560 pages | 107 Color Illus. | 50 B/W Illus.

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Hardback: 9780367028589
pub: 2020-02-19
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Description

This is a comprehensive guide to single-stranded RNA phages (family Leviviridae), first discovered in 1961. These phages played a unique role in early studies of molecular biology, the genetic code, translation, replication, suppression of mutations. Special attention will be devoted to modern applications of the RNA phages and their products in nanotechnology, vaccinology, gene discovery, evolutionary and environmental studies. This overview of the generation of novel vaccines, gene therapy vectors, drug delivery and diagnostic tools will also explore the role of RNA phage-derived products in the revolutionary progress of the protein tethering and bioimaging protocols will be outlined.

Table of Contents

Introduction.

1. History and general properties.

2. Taxonomy.

3. Male specificity, hosts, and natural distribution.

4. Cultivation and preparative biotechnological aspects.

5. Inactivation.

6. Genome organization.

7. Structure of the phage RNA.

8. Genetic studies of RNA phages.

9. RNA phage proteins: coat protein.

10. RNA phage proteins: A protein.

11. RNA phage proteins: replicase protein.

12. RNA phage proteins: lysis protein.

13. Spatial structure of RNA phage particles.

14. Antigenicity and immunogenicity of RNA phages.

15. Translation and genetic code.

16. Replication.

17. Evolutionary experiments.

18. Homologous and heterologous expression of the RNA phage genes.

19. Chimeric virus-like particles.

20. RNA phage VLP-based vaccines.

21. Nonvaccine VLP applications.

22. Non-VLP applications.

23. Environmental applications: water, food, biomedical safety.

24. General conclusions and future perspectives.

About the Author

Paul Pumpens graduated from the Chemical Department of the University of Latvia in 1970, received his PhD in molecular biology from the Latvian Academy of Sciences in Riga, and received his DSc from the Institute of Molecular Biology of the USSR Academy of Sciences in Moscow. He pioneered genetic engineering research in Latvia and was one of the first in the world to successfully clone the hepatitis B virus genome. He is an author of more than 300 scientific papers and issued or pending patents.

Subject Categories

BISAC Subject Codes/Headings:
SCI017000
SCIENCE / Life Sciences / Cytology
SCI045000
SCIENCE / Life Sciences / Biology / Microbiology
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology
SCI086000
SCIENCE / Life Sciences / General