Sleep: Circuits and Functions, 1st Edition (Hardback) book cover


Circuits and Functions, 1st Edition

Edited by Pierre-Herve' Luppi

CRC Press

272 pages | 8 Color Illus. | 48 B/W Illus.

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Hardback: 9780849315190
pub: 2004-09-29
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An estimated 40 million Americans and millions of others worldwide suffer from some type of sleep disruption or disorder, and these numbers are rapidly increasing. As biomedical technologies advance our understanding of sleep, a wave of developments in sleep research and the emergence of new technologies offer hope and help for a good night’s sleep.

Sleep: Circuits and Functions discusses the major discoveries related to the circuits responsible for slow wave sleep, REM sleep, narcolepsy, and the possible role of sleep in memory and developmental processes. World-renowned researcher Pierre-Hervé Luppi and a panel of expert contributors highlight advances in sleep research obtained by means of promising technologies. Data obtained by differential gene expression analysis, transgenic mice, and functional imaging is presented, as well as theoretical concepts on the mechanisms regulating sleep.

Updating our knowledge of the strides made in sleep research, this comprehensive book also identifies future research opportunities in this growing field. It is an essential resource for medical professionals and researchers who aim to finally put sleep disorders to bed.


The text is vivid, the pictures are appropriate, and the text is well written. … [A] good resource on sleep. This is an important book for neuroscience and neurology libraries for its usefulness in both fields. It should be a certain acquisition for those libraries.


Table of Contents


Sleep and Neuronal Plasticity: Cellular Mechanisms of Corticothalamic Oscillations, M. Steriade

Role of Extra-Thalamic Pathways in Sleep and the EEG Oscillations, Maan Gee Lee and Barbara E. Jones

In Vitro Identification of the Presumed Sleep-promoting Neurons of the Ventrolateral Preoptic nucleus (VLPO), Patrice Fort, Pierre-Hervé Luppi, and Thierry Gallopin

Molecular Mechanisms of Sleep-wake Regulation: A Role of Prostaglandin D2 and Adenosine, Osamu Hayaishi

The Network Responsible for Paradoxal Sleep Onset and Maintenance: A New Theory Based on the Head-restrained Rat Model, Pierre-Hervé Luppi, Romuald Boissard, Damien Gervasoni, Laure Verret, Romain Goutagny, Christelle Peyron, Denise Salvert, Lucienne Leger, Bruno Barbagli, and Patrice Fort

Reverse Genetics and the Study of Sleep/Wake Cycle: The Hypocretins and Cortistatin, Luis de Lecea

Genetic Regulation of Sleep, Yves Dauvilliers, Paul Franken and Mehdi Tafti

Searching for Sleep Mutants of Drosophila Melanogaster, Chiara Cirelli and Giulio Tonini


Sleep Phylogeny: Clues of the Evolution and Function of Sleep, Jerome M. Siegel

Sleep, Synaptic plasticity and the Developing Brain, Marcos Gabriel Frank

Changes in Brain Gene Expression Between Sleep and Wakefulness, Giulio Tononi and Chiara Cirelli

Neuronal Reverberation and the Consolidation of New Memories Across the Wake-Sleep Cycle, Sidarta Ribeiro, Damien Gervasoni, and Miguel A.L. Nicolelis Cerebral Functional Segregation and Integration During Human Sleep, Pierre Maquet, Fabien Perrin, Steven Laureys, Than Dang-Vu, Martin Desseilles, Mélanie Boly, and Philippe Peigneux

Subject Categories

BISAC Subject Codes/Headings:
MEDICAL / Anatomy
MEDICAL / Internal Medicine
MEDICAL / Neuroscience
SCIENCE / Chemistry / General