An estimated 40 million Americans and millions of others worldwide suffer from some type of sleep disruption or disorder, and these numbers are rapidly increasing. As biomedical technologies advance our understanding of sleep, a wave of developments in sleep research and the emergence of new technologies offer hope and help for a good night’s sleep.
Sleep: Circuits and Functions discusses the major discoveries related to the circuits responsible for slow wave sleep, REM sleep, narcolepsy, and the possible role of sleep in memory and developmental processes. World-renowned researcher Pierre-Hervé Luppi and a panel of expert contributors highlight advances in sleep research obtained by means of promising technologies. Data obtained by differential gene expression analysis, transgenic mice, and functional imaging is presented, as well as theoretical concepts on the mechanisms regulating sleep.
Updating our knowledge of the strides made in sleep research, this comprehensive book also identifies future research opportunities in this growing field. It is an essential resource for medical professionals and researchers who aim to finally put sleep disorders to bed.
Table of Contents
NEURONAL NETWORKS RESPONSIBLE FOR THE SLEEP-WAKING CYCLE
Sleep and Neuronal Plasticity: Cellular Mechanisms of Corticothalamic Oscillations, M. Steriade
Role of Extra-Thalamic Pathways in Sleep and the EEG Oscillations, Maan Gee Lee and Barbara E. Jones
In Vitro Identification of the Presumed Sleep-promoting Neurons of the Ventrolateral Preoptic nucleus (VLPO), Patrice Fort, Pierre-Hervé Luppi, and Thierry Gallopin
Molecular Mechanisms of Sleep-wake Regulation: A Role of Prostaglandin D2 and Adenosine, Osamu Hayaishi
The Network Responsible for Paradoxal Sleep Onset and Maintenance: A New Theory Based on the Head-restrained Rat Model, Pierre-Hervé Luppi, Romuald Boissard, Damien Gervasoni, Laure Verret, Romain Goutagny, Christelle Peyron, Denise Salvert, Lucienne Leger, Bruno Barbagli, and Patrice Fort
Reverse Genetics and the Study of Sleep/Wake Cycle: The Hypocretins and Cortistatin, Luis de Lecea
Genetic Regulation of Sleep, Yves Dauvilliers, Paul Franken and Mehdi Tafti
Searching for Sleep Mutants of Drosophila Melanogaster, Chiara Cirelli and Giulio Tonini
FUNCTIONS OF SLEEP
Sleep Phylogeny: Clues of the Evolution and Function of Sleep, Jerome M. Siegel
Sleep, Synaptic plasticity and the Developing Brain, Marcos Gabriel Frank
Changes in Brain Gene Expression Between Sleep and Wakefulness, Giulio Tononi and Chiara Cirelli
Neuronal Reverberation and the Consolidation of New Memories Across the Wake-Sleep Cycle, Sidarta Ribeiro, Damien Gervasoni, and Miguel A.L. Nicolelis Cerebral Functional Segregation and Integration During Human Sleep, Pierre Maquet, Fabien Perrin, Steven Laureys, Than Dang-Vu, Martin Desseilles, Mélanie Boly, and Philippe Peigneux
The text is vivid, the pictures are appropriate, and the text is well written. … [A] good resource on sleep. This is an important book for neuroscience and neurology libraries for its usefulness in both fields. It should be a certain acquisition for those libraries.