One of the first such volumes in this field, Sleep Disorders: Diagnosis and Therapeutics explores sleep pharmacology and therapeutics. Leading researchers in the area of experimental and clinical and psychopharmacology critically assess the progress in their specialist fields. The book is suitable as an introduction for clinicians and researchers who are new to sleep pharmacology and outlines the wider range of therapeutic options currently available to them. For seasoned clinicians, the book will assist in selecting the most appropriate methodologies and treatment options designed to circumvent the problems in combating sleep disorders.
Table of Contents
1. Classification of Sleep Disorders 2. Sleep Loss and Sleepiness 3. Approach to the patient with sleep complaint 4. Manifestations of hypersomnia 5. Neuropsychology of Sleep 6. Receptor mechanisms in sleep and wakefulness 7. Transient Insomnia: A Behavioral Sleep Medicine Perspective 8. Chronic insomnia 9. Robound with Hypnotic medication 10. Benzodiazepines: An overview 11. Benzodiazepines: Effects on memory functioning 12. Behavioral therapy, sleep hygiene and psychotherapy 13. Sleep factors 14. The Cytoch P450 enzyme systems: Its relevance to the Pharmacology of sleep 15. Pharmacokinetics: Basic Concepts for dosage regimen considerations 16. Chronopharmacology: Principles and applications in sleep medicine 17. Sleep and Geriatric Psychopharmacology 18. Antihistamines and sleep 19. First generation hypnotics and sedatives 20. GABA-BZD receptors as target for new hypnotics 21. Benzodiazepines: Effects on sleep 22. Indiplon 23. Serotonergic drugs as sleep medications 24. Prostaglandins and sleep/wake regulation 25. Function of endocannabinoids and related compounds in sleep 26. Sleep Medications: When to Prescribe and Rationale for Use 27. Stimulants: Mechanisms and Therapeutic Prospects 28. Zolpidem: its use in the treatment of sleep disorders 29. Eszopiclone: Efficacy and Safety 30. Zaleplon 31. Z-Drugs: Comparative tolerability 32. Rationale for the development of the Z–drugs 33. Metalonin and other indolamines: their involvement in sleep regulation 34. Ramelteon: a Melatonin receptor agonist 35. The rationale for the development of melatonin receptor ligands 36. Schizophrenia, Sleep and Antipsychotic Drugs 37. Interrelationships Between Sleep, Depression and Antidepressant Drugs 38. Effect of antiepileptic medications on sleep architecutre 39. Hormones and sleep 40. Timezone travel, jet lag and sleep disturbances 41. Alcohol, Sleep, Sleep Disorders, and Consequent Daytime Impairment 42. Sleep medication and traffic safety 43. Effect of hypnotic drugs on body balance and standing steadiness 44. Neuropharmacology of Opioids 45. Sleep and Breathing Disorders in Adults 46. Continuous Positive Airway Pressure Therapy 47. Pharmacological Treatment of Obstructive Sleep Apnea 48. Surgical Options in Snoring and Obstructive Sleep Apnea 49. Restless Legs Syndrome: Treatment Options 50. Restless Legs Syndrome: effects on cognitive functioning, memory and psychomotor performance 51. Pharmacological treatment of narcolepsy 52. Modafinil and neuropharmacology of Narcolepsy 53. Narcolepsy: effects on cognitive functioning, memory and psychomotor performance 54. Dreams: Physiology, Pharmacology and Psychology 55. Sleep and Dreaming: Medication effects and side-effects 56. The Subjective Measurement of Excessive Daytime Sleepiness 57. The Multiple Sleep Latency Test and Maintenance of Wakefulness Test: Use and Procedures 58. The OSLER test 59. The Pittsburgh Sleep Quality Index 60. Scoring Rules and General Guidelines for the Pittsburgh Insomnia Rating Scale (PIRS) 61. The Athens Insomnia Scale 62. The Leeds Sleep Evaluation Questionnaire (LSEQ) for psychopharmacology research 63. Sleep Hygiene Practice Scale (SHPS) 64. Cyclic Alternating pattern (CAP) 65. Body Mass Index
S.R. Pandi-Perumal is a Sleep Disorders Specialist at the State University of New York / Downstate Medical Center (SUNY DMC) which is a major provider of medical education, healthcare, and research in the downstate New York region. He is well-recognized sleep researcher both nationally and internationally, and has authored many publications in the field of sleep, dreams, and biological rhythms. He currently holds many professional memberships, including Sleep Research Society, USA and the American Academy of Sleep Medicine, USA. His area of research interest includes sleep and biological rhythms. He has edited many books related to sleep and biological rhythms research and also an editorial member (regular) of Journal of Circadian Rhythms. He was featured in New York Times last year.
Joris C Verster is a researcher in Human Psychopharmacology at the Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, the Netherlands. Verster was born in Breda, the Netherlands in 1970. He graduated in 1997 with a major in Biopsychology. In 2002, Verster became a doctor in psychology. Verster has conducted several outstanding studies in human pschopharmacology, including the residual effects of Zaleplon and Zolpidem on driving ability, cognition, memory functioning and psychomotor performance, the day following middle-of-the-night administration.
Jaime M. Monti is a Professor of Pharmacology and Therapeutics at the School of Medicine, University of the Republic, Montevideo, Uruguay. He is the director of the Sleep Research Laboratory at the Department of Pharmacology and Therapeutics at the School of Medicine. Prof. Monti received his medical degree from the University of the Republic, and completed a post-doctoral psychopharmacology research training fellowship at the University of Stanford, California, USA. Since 1970, Prof. Monti has published over one hundred and fifty peer reviewed articles and book chapters and twenty invited publications on sleep research topics. His primary research interest includes insomnia and experimental and clinical pharmacology of sleep. He has served on the editorial board of several journals, including Sleep, the Journal of Sleep Research, and Sleep Medicine Reviews, and as a Consultant to the WHO. He is a past president of Latinamerican Society of Sleep Research and the Latinamerican Society of Pharmacology and Therapeutics.
Malcolm Harold Lader is Emeritus Professor of Clinical Psychopharmacology at the Institute of Psychiatry, Kings College London, University of London. Professor Lader was also an Honorary Consultant at the Bethlem Royal and Maudsley Hospital (a Post-graduate Teaching Hospital) and conducted and supervised clinics dealing with anxiety, sleep and depressive disorders and drug treatment problems for many years. His experience in psychiatry and clinical pharmacology now extends to over 40 years. His main research interest is the drugs used in psychiatry, in particular, antidepressants and anxiolytics. These researches have resulted in the publication of 15 books and about 640 scientific articles. He has lectured widely in many countries.
He advises the UK Ministries of Health, Defence and Transport in various capacities. He is a member of other national and regional advisory committees. He is on the advisory boards of about 30 international scientific journals. Professor Lader is an adviser to the World Health Organisation on drugs used in psychiatry. He is an Honorary Fellow of the American College of Psychiatry. He has been Vice-President of the International College of Psychopharmacology, President of the Society for the Study of Addiction and President of the British Association for Psychopharmacology. Professor Lader was a member of the Committee on the Review of Medicines from 1978 – 1989, and was involved in the regulation and licensing of medicines. Professor Lader was a member of the Home Office’s Advisory Council on Misuse of Drugs from 1981-2000, and Chairman of its Technical Committee from 1984-2000, and advised on drugs of addiction.
Professor Lader trained in physiology with biochemistry, medicine, pharmacology and psychiatry and has formal qualifications in each of these disciplines. He is a Fellow of the Royal College of Psychiatrists, and of the prestigious Academy of Medical Sciences.
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