Of recent, the structure of the complement system has received considerable attention, including the publication of several three-dimensional structures of complement proteins. This has led to the need for an authoritative resource to provide a complete overview of the basics, as well as an explanation of the cutting-edge work being accomplished in this emerging science.
Structural Biology of the Complement System is devoted to the full exploration of structural aspects of the complement system, with special consideration of the links between molecular structure and function.
Containing the work of leading authorities across the disciplines of immunology and structural biology, the book serves both as an introductory volume for newcomers to the field and as a comprehensive reference for established researchers, in particular those whose goal is the discovery of anticomplement drugs. Written in a didactic style, this volume is an appropriate resource for students in the fields of immunology and structural biology.
Structural Biology of the Complement System comes with downloadable resources containing color figures, a molecular structure visualization program, and files with three-dimensional coordinates of the structures described in the book. These tools allow readers to perform tailored structural manipulation and analysis, while also serving as a starting point for further research.
Table of Contents
The Building Blocks of the Complement System, D. Morikis and J. D. Lambris
Complement Control Protein Modules in the Regulators of Complement Activation , D. C. Soares and P. N. Barlow
The Classical Pathway C1 Complex, G. J. Arlaud, C. Gaboriaud, N. M. Thielens, L. A. Gregory, J. Juanhuix, V. Rossi, and J. C. Fontecilla-Camps
Factors D and B: Substrate-Inducible Serine Proteases of the Alternative Pathway of Complement Activation, Yuanyuan Xu, Karthe Ponnuraj, Sthanam V. L. Narayana, and John E. Volanakis
The Structures of Human Complement Fragments C3d and C4Ad and the Functional Insights That They Have Provided , D. E. Isenman and J. M. H. van den Elsen
Complement Receptor CR2/CD21 and CR2-C3d Complexes , J. P. Hannan, G. Szakonyi, R. Asokan, X. Chen, and V. M. Holers
Structure of the Anaphylatoxins C3a and C5a, D. Morikis, M. C. H. Holland, and J. D. Lambris
C3b/C4b Binding Site of Complement Receptor Type 1 (CR1, CD35), M. Krych-Goldberg, P. N. Barlow, R. L. Mallin, and J. P. Atkinson
From Structure to Function of a Complement Regulator:
Decay-Accelerating Factor (CD55), P. Lukacik, P. Roversi, R. A. G. Smith, and S. M. Lea
Complement Protein C8, L. Lebioda and J. M. Sodetz
Structure-Function Relationships in CD59, B. P. Morgan and S. Tomlinson
Complement-like Repeats in Proteins of the Complement System, K. Dolmer and P. G. W. Gettins
Complement and Immunoglobulin Protein Structures by X-Ray and Neutron Solution Scattering and Analytical Ultracentrifugation, S. J. Perkins and B. Furtado
Structure, Dynamics, Activity, and Function of Compstatin and Design of More Potent Analogues ,
D. Morikis and J. D. Lambris
Discovery of Potent Cyclic Antagonists of Human C5a Receptors, S. M. Taylor and D. P. Fairlie
Morikis\, Dimitrios; Lambris\, John D.
"…This is a unique book that offers information about what is currently known about the structure-function relationship of the complement system components. For researchers with an interest in this particular area, it would be an excellent source of information."
-Doody's Review Services