Structural Glycobiology: 1st Edition (Hardback) book cover

Structural Glycobiology

1st Edition

Edited by Elizabeth Yuriev, Paul A. Ramsland

CRC Press

347 pages | 37 Color Illus. | 62 B/W Illus.

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Hardback: 9781439854600
pub: 2012-09-27
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pub: 2012-09-27
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Description

Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on:

  • X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques
  • Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking
  • Alternative techniques for yielding structural information on carbohydrates from complex biological samples
  • Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection

Reviews

"… beautifully illustrated with fine color illustrations … valuable for a wide audience - from graduate students to established researchers involved in studies of carbohydrates as well as for specialists in the other fields - biochemists, clinical chemists and immunologists."

Immunological Investigations, 2013

Table of Contents

Experimental Techniques to Determine Three-Dimensional Structures

Crystallography and Small-Angle Scattering of Carbohydrate–Protein Complexes and Glycoproteins

Cy M. Jeffries, William Farrugia, and Paul A. Ramsland

Nuclear Magnetic Resonance Studies of Carbohydrate–Protein Interactions

Leonardus M. I. Koharudin and Angela M. Gronenborn

Electron Cryomicroscopy of Large Glycoprotein Assemblies

Tzviya Zeev-Ben-Mordehai and Kay Grünewald

Theoretical/Modeling Techniques to Predict Three-Dimensional Structures

Protein–Carbohydrate Interactions: Computational Aspects

Anita Sarkar and Serge Pérez

Docking of Carbohydrates into Protein Binding Sites

Mark Agostino, Paul A. Ramsland, and Elizabeth Yuriev

Alternative Approaches for Yielding Detailed Structural Information

Mass Spectrometry for Glycomics Analysis of N- and O-Linked Glycoproteins

Daniel Kolarich and Nicolle H. Packer

Glycan-Based Arrays for Determining Specificity of Carbohydrate-Binding Proteins

Xuezheng Song, David F. Smith, and Richard D. Cummings

Carbohydrates in Medicine

Structural Glycobiology: Applications in Cancer Research

Inka Brockhausen and Yin Gao

Structural Glycobiology: Applications in Organ Transplantation

Dale Christiansen, Mark Agostino, Elizabeth Yuriev, Paul A. Ramsland, and Mauro S. Sandrin

Structural Glycobiology: Applications in Viral Infection

Rui Xu and Ian A. Wilson

Developing Drugs from Sugars Current State of Glycosaminoglycan-Derived Therapeutics

Neha S. Gandhi and Ricardo L. Mancera

About the Editors

Editor

Elizabeth Yuriev is with the Monash Institute for Pharmaceutical Sciences at Monash University, Australia. Paul A. Ramsland is with the Centre for Immunology at the Burnet Institute in Melbourne, Australia.

Subject Categories

BISAC Subject Codes/Headings:
MED008000
MEDICAL / Biochemistry
SCI013000
SCIENCE / Chemistry / General
SCI049000
SCIENCE / Life Sciences / Biology / Molecular Biology