Structural Glycobiology  book cover
1st Edition

Structural Glycobiology

ISBN 9781439854600
Published September 27, 2012 by CRC Press
348 Pages 37 Color & 62 B/W Illustrations

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Book Description

Structural Glycobiology covers the experimental, theoretical, and alternative technologies used in the study of the structural basis for the diverse biological roles of carbohydrates. The book overviews the application of specialized technologies to the study of carbohydrates in biology, reviews relevant and current research in the field, and is illustrated throughout by specific examples of how research investigations have yielded key structural and associated biological data on carbohydrates and glycolipids. In particular, the book focuses on:

  • X-ray crystallography and small-angle scattering, NMR, and cryo-electron microscopy techniques
  • Theoretical (modeling-based) approaches, such as molecular mechanics, molecular dynamics, free energy calculations, and carbohydrate docking
  • Alternative techniques for yielding structural information on carbohydrates from complex biological samples
  • Carbohydrates in medicine, specifically in areas that have been directly impacted by our understanding of the structural role of carbohydrates in immune recognition: cancer, organ transplantation, and infection

Table of Contents

Experimental Techniques to Determine Three-Dimensional Structures
Crystallography and Small-Angle Scattering of Carbohydrate–Protein Complexes and Glycoproteins
Cy M. Jeffries, William Farrugia, and Paul A. Ramsland
Nuclear Magnetic Resonance Studies of Carbohydrate–Protein Interactions
Leonardus M. I. Koharudin and Angela M. Gronenborn
Electron Cryomicroscopy of Large Glycoprotein Assemblies
Tzviya Zeev-Ben-Mordehai and Kay Grünewald

Theoretical/Modeling Techniques to Predict Three-Dimensional Structures
Protein–Carbohydrate Interactions: Computational Aspects
Anita Sarkar and Serge Pérez
Docking of Carbohydrates into Protein Binding Sites
Mark Agostino, Paul A. Ramsland, and Elizabeth Yuriev

Alternative Approaches for Yielding Detailed Structural Information
Mass Spectrometry for Glycomics Analysis of N- and O-Linked Glycoproteins
Daniel Kolarich and Nicolle H. Packer
Glycan-Based Arrays for Determining Specificity of Carbohydrate-Binding Proteins
Xuezheng Song, David F. Smith, and Richard D. Cummings

Carbohydrates in Medicine
Structural Glycobiology: Applications in Cancer Research
Inka Brockhausen and Yin Gao
Structural Glycobiology: Applications in Organ Transplantation
Dale Christiansen, Mark Agostino, Elizabeth Yuriev, Paul A. Ramsland, and Mauro S. Sandrin
Structural Glycobiology: Applications in Viral Infection
Rui Xu and Ian A. Wilson
Developing Drugs from Sugars Current State of Glycosaminoglycan-Derived Therapeutics
Neha S. Gandhi and Ricardo L. Mancera

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Elizabeth Yuriev is with the Monash Institute for Pharmaceutical Sciences at Monash University, Australia. Paul A. Ramsland is with the Centre for Immunology at the Burnet Institute in Melbourne, Australia.

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Author - Elizabeth  Yuriev

Elizabeth Yuriev

Senior Lecturer, Monash Institute of Pharmaceutical Sciences, Monash University
Melbourne, Victoria, Australia

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"… beautifully illustrated with fine color illustrations … valuable for a wide audience - from graduate students to established researchers involved in studies of carbohydrates as well as for specialists in the other fields - biochemists, clinical chemists and immunologists."
Immunological Investigations, 2013