Structure of Antigens discusses a variety of topics dealing with the structural basis of antigenicity. Topics include the analytical methods used to elucidate the structure of antigens, the structure of antibodies, the principles underlying modern immunoassays and the measurement of antibody binding affinity, and physicochemical principles and methodological aspects. The book also considers major groups of antigens distinguished by their functional activity and biological role (e.g., drugs, autoantigens, snake toxins, allergens) or by their association with particular biological systems (e.g., antigens of microorganisms).
Structure of Antigens will provide a current, useful, reference for researchers and graduate students in all fields of biological science who need an overview of antigenic specificity.
Table of Contents
An Atlas of Antibody Combining Sites (Arthur M. Lesk and Anna Tramontano). Structural Basis of Antigenic Cross-Reactivity (Victoria A. Roberts, Elizabeth D. Getzoff, and John A. Tainer). Antigen Processing and Presentation (Christian Widmann and Giampietro Corradin). Expression of Antigens as Recombinant Proteins (Maurice Hofnung and Alain Charbit). Nucleic Acids and Cross-Reactive Antigens (David S. Pisetsky). Histones (Sylviane Muller and Marc H.V. Van Regenmortel). Soluble RNP Autoantigens (Michael R. Saitta and Jack D. Keene). Fungal Antigens (Veronica M. Hearn, G.T. Cole, and S. Suzuki). Parasite Antigens (Colette Dissous, Raymond J. Pierce, Marie-France Cesbron, and André Capron). Allergens (Said Elsayed). Carbohydrate Antigens in Human Cancer (Christopher S. Foster, Aristotelis Bamias, and Agamemnon Epenetos). The Carcinoembryonic Antigen Family (Sten Hammarström, Wasif Noor Khan, Stephan Teglund, Marie-Louise Hammarström, Teresa Ramos, Moorix Mo-Wai Yeung, and Lars Frängsmyr). Index.