Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks, 1st Edition (Hardback) book cover

Sudden Unexpected Death in Epilepsy

Mechanisms and New Methods for Analyzing Risks, 1st Edition

Edited by Claire M. Lathers, Paul L. Schraeder, Jan E. Leestma, Braxton B. Wannamaker, Richard L. Verrier, F.A.C.C., Ph.D., Steven C. Schachter, MD

CRC Press

350 pages | 63 B/W Illus.

Purchasing Options:$ = USD
Hardback: 9781482223859
pub: 2015-04-06
$145.00
x
eBook (VitalSource) : 9780429255991
pub: 2015-04-06
from $72.50


FREE Standard Shipping!

Description

Sudden Unexpected Death in Epilepsy: Mechanisms and New Methods for Analyzing Risks builds on earlier works focusing on the clinical problem of sudden unexpected death in epilepsy (SUDEP). This book presents a methodology for identifying and classifying clusters of risks that lead to SUDEP. Developed over the last two years, the SUDEP Classification System and Risk Factor Cluster ID method will help to address gaps in our knowledge about the causes and possible prevention of this tragic complication.

Exploring the interactions among the central and peripheral autonomic nervous systems and the cardiopulmonary systems, the book includes case studies of SUDEP, definite or probable, as well as near miss cases. It discusses how neurologists, emergency room physicians, and attending physicians can identify individuals at possible risk for SUDEP and lessen the chance of occurrence. Top medical professionals in the field detail the development of an international database of human cases and animal models of SUDEP and suggest how medical examiner and coroner offices can strengthen the database by providing information about incidences of SUDEP. In addition, the book describes related clinical and animal studies needed to classify risk factors for SUDEP victims.

Understanding the risk factors and mechanisms underlying SUDEP will facilitate collaborative research in the laboratory, hospital, and clinic and lead to improved effectiveness of SUDEP prevention strategies.

Table of Contents

Forensics of SUDEP and Cluster Risk Factor Identification

Mechanistic Mystery: Risk Factors in SUDEP; Claire M. Lathers, Steven C. Schachter, Jan E. Leestma, Steven A. Koehler, H. Gregg Claycamp, Braxton B. Wannamaker, and Paul L. Schraeder

SUDEP: A Syndrome with Several If Not Many Potential Underlying Mechanisms; Claire M. Lathers, Steven C. Schachter, Jan E. Leestma, Steven A. Koehler, H. Gregg Claycamp, Braxton B. Wannamaker, and Paul L. Schraeder

Unravel the Global Mystery of SUDEP; Claire M. Lathers, Steven C. Schachter, Jan E. Leestma, Steven A. Koehler, H. Gregg Claycamp, Braxton B. Wannamaker, and Paul L. Schraeder

Decision Analysis and Classification Methods for SUDEP Risk Factor Identification; H. Gregg Claycamp, Claire M. Lathers, Paul L. Schraeder, and Braxton B. Wannamaker

Forensic SUDEP Cluster Risk Factor Identifier Method; Claire M. Lathers, Jan E. Leestma, Steven C. Schachter, Steven A. Koehler, H. Gregg Claycamp, Braxton B. Wannamaker, and Paul L. Schraeder

Forensic Cases Classified as SUDEP Cluster Risk Factor Identifiers; Claire M. Lathers, Paul L. Schraeder, and Steven A. Koehler

How to and How Not to Use Cluster ID Method; Paul L. Schraeder and Claire M. Lathers

Clinical Cases Classified as SUDEP Cluster Risk Factor Identifiers; Claire M. Lathers, Paul L. Schraeder, Steven C. Schachter, Richard L. Verrier, and Braxton B. Wannamaker

SUDEP: Continued Forensic Challenges; Jan E. Leestma and Claire M. Lathers

A South Carolina Cohort of Epilepsy Patients; Angela M. Malek and Braxton B. Wannamaker

Measuring the Incidence of SUDEP Using Forensic and National Data; Steven A. Koehler, Claire M. Lathers, and Paul L. Schraeder

Risk Predictor: Individual SUDEP Risk Factor Cluster IDs; Claire M. Lathers, Steven C. Schachter, Braxton B. Wannamaker, and Jan E. Leestma

Intracranial Pressure, Cerebral Edema, and Obstructive Sleep Apnea: A Risk Factor Cluster for SUDEP? Claire M. Lathers, Steven C. Schachter, Braxton B. Wannamaker, and Jan E. Leestma

Neurocardiac Interactions in Sudden Unexpected Death in Epilepsy: Can Ambulatory Electrocardiogram-Based Assessment of Autonomic Function and T-Wave Alternans

Help to Evaluate Risk? Richard L. Verrier and Steven C. Schachter

Patient Management Using Cluster Risk Factor Identifiers; Claire M. Lathers, Steve C. Schachter, Paul L. Schraeder, and Braxton B. Wannamaker

Future Clinical and Animal Studies; Claire M. Lathers, Steven C. Schachter, and Paul L. Schraeder

Animal Model Cluster IDs: Mechanisms and Risk Factors for SUDEP; Claire M. Lathers

SUDEP Animal Models: Mechanisms of Risks

Sudden Death Animal Models to Study Nervous System Sites of Action for Disease and Pharmacological Intervention; Claire M. Lathers

A Characterization of the Lockstep Phenomenon in Phenobarbital-Pretreated Cats; Jeffrey M. Dodd-O and Claire M. Lathers

Relationship of the Lockstep Phenomenon and Precipitous Changes in Blood Pressure; Amy Z. Stauffer, Jeffrey M. Dodd-O, and Claire M. Lathers

Interspike Interval Histogram Characterization of Synchronized Cardiac Sympathetic Neural Discharge and Epileptogenic Activity in the Electrocorticogram of the Cat; Daniel K. O’Rourke and Claire M. Lathers

SUDEP Risk Mechanisms: Animal Models and Clinical Studies

Abnormal Brain Activity Triggers Long-Term Potentiation in Sympathetic Ganglia: Implication for Sudden Death; Karim Alkadhi and Karem Alzoubi

β1-Adrenergic Blockade Prevents Cardiac Dysfunction and Increased Susceptibility to Experimental

Arrhythmias Following Status Epilepticus in Rats; Steven L. Bealer, Cameron S. Metcalf, and Jason G. Little

Cardiac Myocyte Damage, Electrocardiographic Dysfunction, and Ion Channel Remodeling in Rodent Models of Seizure Disorders; Steven L. Bealer, Cameron S. Metcalf, Steven Poelzing, Jason G. Little, Amy Brewster, and Anne Anderson

A Rat Model for Exploring the Contributions of Ventricular Arrhythmias to Sudden Death in Epilepsy; Isaac Naggar and Mark Stewart

Neurotransmitters Implicated in Control of Sudden Unexpected Death in Epilepsy in Animal Models; Carl L. Faingold, Marc Randall, Xiaoyan Long, Victor V. Uteshev, Srinivasa P. Kommajosyula, and Srinivasan Tupal

n-3 Fatty Acids and Sudden Unexpected Death in Epilepsy: A Translational Approach; Fulvio A. Scorza, Esper A. Cavalheiro, Antonio-Carlos G. de Almeida, Carla A. Scorza, Mariana B. Nejm, and Roberta M. Cysneiros

Sudden Death in Epilepsy: Relationship to the Sleep–Wake Circadian Cycle and Fractal Physiology; John D. Hughes and Susumu Sato

Lockstep in Humans: Bridging the Gap; Jeremy D. Slater

Postictal Generalized EEG Suppression and Sudden Unexpected Death in Epilepsy; Joon Kang and Maromi Nei

Mechanisms of SUDEP: Lessons from Cases Occurring in the Epilepsy Monitoring Unit; Torbjörn Tomson, Lina Nashef, and Philippe Ryvlin

Compliance with Antiepileptic Drug Treatment and the Risk of SUDEP; Torbjörn Tomson

Providing Information about SUDEP: The Benefits and Challenges; Rosemary Panelli, W. Henry Smithson, and Jane Hanna

Mechanistic SUDEP Risk Factor Studies for Animals and Humans; Claire M. Lathers, Steven C. Schachter, Braxton B. Wannamaker, Jan E. Leestma, and Paul L. Schraeder

Index

About the Editors

Claire M. Lathers, PhD, FCP, has been credentialed as a senior biomedical research scientist by the FDA for international recognition of her work in the two areas of cardiovascular autonomic dysfunction associated with sudden death in persons with epilepsy and with space flight and for her professional management experience in drug development, the business world, and clinical pharmacology. The primary focus of her international cardiovascular pharmacology research career has centered on autonomic peripheral and central mechanisms involved in the control and regulation of blood pressure, heart rate and rhythm, and electroencephalogram. Dr. Lathers served as President Clinton’s lead person on the Food Safety Program at FDA, was Director of the Office of New Animal Drug Evaluation and a Senior Advisor for Science at FDA.

Paul L. Schraeder, MD, FAAN, is Professor Emeritus of Neurology at Drexel University College of Medicine. Along with Dr. Lathers, Dr. Schraeder has spent over three decades studying and investigating the mystery of SUDEP and developed the first experimental animal models of this fatal phenomenon. Dr. Schraeder organized a collaborative nationwide survey of how coroners and medical examiners evaluate the deaths of persons with a history of epilepsy.

Jan E. Leestma, MD, MBA, is licensed as a physician in the states of Illinois and Michigan and certified by the American Board of Pathology in both Anatomic Pathology and Neuropathology. His areas of expertise and publication history include sudden unexpected death in epilepsy, viral infections of the central nervous system, and forensic neuropathology.

Braxton B. Wannamaker, MD, FAAN is Clinical Professor of Neurology at the Medical University of South Carolina (MUSC). In his long career devoted to comprehensive care of persons with epilepsy, Dr. Wannamaker has served as a member of the NINDS Epilepsy Advisory Committee, as a board member of the Epilepsy Foundation of America, and as president of the American Epilepsy Society.

Richard L. Verrier, PhD, FACC, is Associate Professor of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts. He has investigated autonomic factors in sudden cardiac death for over 25 years in both clinical and experimental studies. He demonstrated that the phenomenon of T-wave alternans (TWA) is strongly correlated with ventricular fibrillation, the arrhythmia responsible for sudden cardiac death in patients with cardiovascular disease.

Steven C. Schachter, MD, is Professor of Neurology at Harvard Medical School; chief academic officer and director of neurotechnology for the Consortia for Improving Medicine Through Innovation and Technology in Boston, Massachusetts; and senior neurologist at Beth Israel Deaconess Medical Center, Boston. He has directed over 70 research projects involving antiepileptic therapies and published over 200 articles and chapters. He compiled the six-volume Brainstorms series, and edited or wrote 23 other books on epilepsy and behavior.

Subject Categories

BISAC Subject Codes/Headings:
LAW041000
LAW / Forensic Science
MED056000
MEDICAL / Neurology
MED078000
MEDICAL / Public Health