Taylor & Francis
350 pages | 45 B/W Illus.
The molecular and biochemical mechanisms involved in sumoylation have been the subject of intense interest in recent years. This volume, edited and written by leading international experts, is the first book to be devoted to sumoylation. It presents information on the history, evolution and mechanisms of sumoylation, discusses SUMO proteases, ligases and conjugation pathways, and reviews the impact on modification and nucleocytoplasmic transport, PML nuclear bodies, and transcriptional regulation. In addition, specialist chapters cover the role of sumoylation in yeast, viruses and the tumor suppressor P53.
1. Historical Introduction to SUMO Modification. 2. The Molecular Evolution of SUMO Proteins. 3. Molecular Mechanism of Sumoylation. 4. SUMO Proteases. 5. SUMO E3 Ligases. 6. Unravelling the SUMO-2/3 Conjugation and De-conjugation Pathways. 7. Sumoylation in Yeast. 8. PML Nuclear Bodies and Sumoylation. 9. SUMO Modification and Nucleocytoplasm Transport. 10. SUMO and Transcriptional Regulation. 11. Viruses and Sumoylation. 12. Sumoylation of Tumor Supressor p53 and of its Ubiquitin Ligase, Mdm2.