1st Edition

Molecular Biology: Immunology, and Relevance to Human Disease



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ISBN 9780824798130
Published February 20, 1997 by CRC Press
624 Pages

USD $425.00

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Book Description

This up-to-date sourcebook covers viral and bacterial superantigens (SAgs) from molecular structure and immunological processes to pathology and treatment of superantigen-mediated human diseases. Discusses diseases beyond Toxic Shock Syndrome, such as autoimmune and inflammatory skin conditions, as well as the role of superantigens in other infectious diseases. Illustrated with molecular structures of superantigens.

Table of Contents

Historical Perspective of Superantigens and Their Biologic Activities, Donald Y. M. Leung, Brigitte T. Huber, and Patrick M. Schlievert
Immunobiology of MMTV Superantigens, Susan R. Ross
Structural Features of MMTV Superantigens, Gary Winslow, John W. Kappler, and Philippa Marrack
Interaction of Superantigens with MHC Class II Molecules, Pascal M. Lavoie, Rafick-Pierre Sékaly, Jacques Thibodeau,and François Denis
Superantigen in Rabies Virus and Its Involvement in Paralysis, Monique Lafon
Superantigen Associated with Epstein-Barr Virus: Potential Role in Tumor Formation, Natalie Sutkowski and Brigitte T. Huber
Toxic Shock Syndrome Toxin-1: Molecular Structure and Basis for T-Cell Recognition, Cathleen A. Earhart, David T. Mitchell, Debra L. Murray, Patrick M. Schlievert, and Douglas H. Ohlendorf
Comparison of Structures of Toxic Shock Syndrome Toxin-1 Unbound and Bound to a Class II Major Histocompatibility Molecule, David T. Mitchell, Patrick M. Schlievert, Douglas H. Ohlendorf, Jongsun Kim, Don C. Wiley, Robert G. Urban, and Jack L. Strominger
Staphylococcal Enterotoxin B and C: Structural Requirements for Superantigenic and Entertoxigenic Activities, Gregory A. Bohach
Staphylococcal Enterotoxin A, D and E: Structure and Function, Including Mechanism of T-Cell Superantigenicity, L. Anders Svensson, Elinor M. Schad, Michael Sundström, Per Antonsson, Terje Kalland, and Mikael Dohlsten
The Exfoliative Toxins of Staphylococcus aureus, John J. Iandolo and Stephen Keith Chapes
Molecular Genetics, Structure, and Immunobiology of Streptococcal Pyrogenic Exotoxins A and C, Michael H. Kim and Patrick M. Schlievert
Streptococcal Superantigen, Mitogenic Factor, and Pyrogenic Exotoxin B Expressed by Streptococcus pyogenes: Structure and Function, James M. Musser
Streptococcal M Protein: Role in Post-Streptococcal Autoimmunity, Malak Kotb
The Superantigen Mycoplasma arthritidis Mitogen (MAM): Physical Properties and Immunobiology, Kevin L. Knudtson, Allen D. Sawitzke, and Barry C. Cole
Characterization of a Superantigen Produced by Yersinia pseudotuberculosis, Jun Abe and Tae Takeda
B-Cell Superantigens and Their Biological Implications, Arnold I. Levinson and Lisa M. Kozlowski
Staphylococcal Toxic Shock Syndrome, Robert L. Deresiewicz
Streptococcal Toxic Shock Syndrome, Dennis L. Steves
Viral Superantigens in Humans: A Potential Role in HIV and CMV Infection, David N. Posnett
Superantigens in Autoimmunity: Their Role as Etiologic and Therapeutic Agents, Joel Schiffenbauer, Howard Johnson, and Jeanne Soos
Superantigens in Inflammatory Skin Diseases: A Role in Disease Maintenance and Induction, David A. Norris and Donald Y. M. Leung
Superantigens in Human Disease: Future Directions in Therapy and Elucidation of Disease. Pathogenesis, Donald Y. M. Leung and Patrick M. Schlievert

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