This reference provides a clear understanding of the basic mechanisms of synaptic transmission and information processing and illustrates potential clinical applications for the recovery of lost function as a result of gene defects, injury, or disease-relating the most recent advances in the design of new therapeutics, the treatment of neurological disease and age-related loss of cognitive function, rehabilitation therapy, and neural engineering and computation.
Table of Contents
Basic Mechanisms. Memory: From Molecular Mechanisms to Clinical Applications. Synaptogenesis as a Correlate of Activity-Induced Plasticity Volume Transmission: Role in the Carry-Over Functional Effect in Tactile Vestibular Substitution. Lysosomal Dysfunction and Neurotrophic Signaling in Brain Aging and Alzheimer's Disease. Axonal Sprouting in the Adult Brain: Mechanisms of Lesion-Specific Sprouting of the Cortico-Striatal Pathway in Adult Rats. Behavioral Implications of Activity-Dependent Regulation of Neurotrophins. Estrogen Therapy for Prevention of Alzheimer's Disease. Clinical Applications. The Use of PET to Evaluate Neural Plasticity and Repair in Rodents. Use of Estrogens as Neuroprotectants in Stroke and Alzheimer's Disease. Cell Death after Spinal Cord Injury. Motor Rehabilitation after Stroke: Novel Physical Treatment Strategies. Neural Bases for Rehabilitation After Stroke. Locomotor Training-Induced Plasticity. Constraint-Induced Therapy for Functional Recovery After Stroke: Unraveling the Key Ingredients and Mechanisms. Stem Cell Grafting and Spinal Cord Injury. Stem Cells and Huntington's Disease. Plasticity, Cell Transplantation, and Brain Repair. Neural Engineering and Neural Computation. Behaviorally Relevant Neural Codes in Hippocampal Ensembles: Detection on Single Trials. Recent Advances Toward Development of Practical Brain-Machine Interfaces. Brian-Implantable Iomimetic Electronics as Neural Prostheses to Restore Lost Cognitive Function