This book provides an analysis of the current subdisciplines comprising the study of humoral immune response. The first chapter presents a detailed discussion regarding the experimental and conceptual studies conducted prior to the mid-1970s that have served as a valuable research framework for investigators interested in the process by which B cells are activated following their exposure to antigens. Other chapters focus on topics such as membrane-associated proteins with important functional roles during B cell activation and differentiation; thymus-independent and thymus-dependent activation; mechanisms operative during B-T cell interactions, including the role of B cells as antigen-presenting cells; and the importance of soluble mediators. Additional topics include the regulatory role of T cells during B cell repertoire expression, memory development, tolerance, and autoimmunity. T-Cell Dependent and Independent B-Cell Activation is an important history and reference resource for humoral immune response investigators, as well as advanced graduate and medical students.
The Humoral Immune Response-A Historical Perspective (E. Charles Snow). The Surface Immunoglobulin Receptor (E. Charles Snow). Functionally Important B Cell Surface Molecules (Bondada Subbarao, Arthur Baluyut, and Natarajan Muthusamy). Thymus-Independent Antigens (Goran Moller, Carmen Fernandez, and Marta Alarcon-Riquelme). Antigen Presentation by B Cells (Tania H. Watts, Yves St-Pierre, and Jonathan M. Lee). T Cell Dependent B Cell Activation (William C. Bartlett and Randolph J. Noelle). T Cell Dependent Activation of Human B Cells (Robin E. Callard). Cytokines and Their Role in Antibody Class Expression (Judy M. Teale and D. Mark Estes). B Cell Responses to Natural Antigens: Repertoire Analyses and V Gene Family Utilization (Eleanor S. Metcalf). Helper T Cells and the Maturation of the B Cell Response to Antigen (Suzanne Fish and Tim Manser). T Cell Control of Memory Development (Thomas L. Feldbush, David Leitenberg, and Helen Braley-Mullen). B Cell Tolerance (Tom Waldschmidt). Regulation of Natural Autoantibodies: Benign vs. Disease-Causing Self-Reactivities (Keith A. Krolick).